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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Metabolic Enzyme & Protease > CelastrolCAS：34157-83-0
Molecular Formula：C29H38O4
Molecular Weight：450.61
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：Red Solid
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| CAS | 34157-83-0 |
| Name | Celastrol |
| Molecular Formula | C29H38O4 |
| Molecular Weight | 450.61 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | Red Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 636-472-5 |
| MDL | MFCD03424073 |
| SMILES | OC1=C(C2=CC=C3[C@](C)([C@]4(CC[C@]3(C2=CC1=O)C)C)CC[C@@]5(C)CC[C@@](C(O)=O)(C[C@]54[H])C)C |
| InChIKey | KQJSQWZMSAGSHN-JJWQIEBTSA-N |
| InChI | InChI=1S/C29H38O4/c1-17-18-7-8-21-27(4,19(18)15-20(30)23(17)31)12-14-29(6)22-16-26(3,24(32)33)10-9-25(22,2)11-13-28(21,29)5/h7-8,15,22,31H,9-14,16H2,1-6H3,(H,32,33)/t22-,25-,26-,27+,28-,29+/m1/s1 |
| PubChem CID | 122724 |
| Target Point | Proteasome |
| Passage | Metabolic Enzyme&Protease |
| Background | Celastrol is a proteasome inhibitor that potently and preferentially inhibits the chymotrypsin-like activity of the 20S proteasome. |
| Biological Activity | Tripterin (Celastrol) 是一种蛋白酶体抑制剂，有效且优先抑制20S 蛋白酶体的胰凝乳蛋白酶样活性，IC50 为2.5 μM。[1] |
| IC50 | 2.5μM(20S proteasome)[1] |
| Data Literature Source | [1]. Yang H，et al. Celastrol，a triterpene extracted from the Chinese 'Thunder of God Vine，' is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice. Cancer Res. 2006 May 1;66(9):4758-65 [2]. Guan Y，et al. Celastrol attenuates oxidative stress in the skeletal muscle of diabetic rats by regulating the AMPK-PGC1α-SIRT3 signaling pathway. Int J Mol Med. 2016 May;37(5):1229-38. |
| Unit | Bottle |
| Specification | 10mg 10mM*1mL in DMSO |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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Anticariogenic Activity of Celastrol and Its Enhancement of Streptococcal Antagonism in Multispecies Biofilm
Click to check >>Author：Hao Li, Chenguang Niu, Junyuan Luo, Zhengwei Huang, Wei Zhou
IF：4.8000
Publish_to：Antibiotics-Basel
PMID：37627665
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