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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Metabolic Enzyme & Protease > Chenodeoxycholic AcidCAS：474-25-9
Molecular Formula：C24H40O4
Molecular Weight：392.57
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 474-25-9 |
| Name | Chenodeoxycholic Acid |
| Molecular Formula | C24H40O4 |
| Molecular Weight | 392.57 |
| Solubility | Soluble in DMSO ≥50mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 207-481-8 |
| MDL | MFCD00064142 |
| SMILES | O=C(O)CC[C@@H](C)[C@]1([H])[C@]2(C)[C@](CC1)([H])[C@]3([H])[C@H](O)C[C@@](C4)([H])[C@@](CC[C@H]4O)(C)[C@]([H])3CC2 |
| InChIKey | RUDATBOHQWOJDD-BSWAIDMHSA-N |
| InChI | InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 |
| PubChem CID | 10133 |
| Target Point | FXR |
| Passage | Metabolic Enzyme&Protease |
| Background | Chenodeoxycholic Acid can activate nuclear receptor FXR, which is related to cholesterol metabolism. The main function is to reduce cholesterol saturation in bile, so as to dissolve and shed cholesterol in stones. |
| Biological Activity | Chenodeoxycholic Acid 是一种疏水初级胆汁酸，能够活化核受体 FXR，该受体与胆固醇代谢有关[1-5]。 |
| Data Literature Source | [1]. Stauffer AT，et al. Chenodeoxycholic acid and deoxycholic acid inhibit 11 beta-hydroxysteroid dehydrogenase type 2 and cause cortisol-induced transcriptional activation of the mineralocorticoid receptor. J Biol Chem. 2002 Jul 19;277(29):26286-92 [2]. Casaburi I，et al. Chenodeoxycholic acid through a TGR5-dependent CREB signaling activation enhances cyclin D1 expression and promotes human endometrial cancer cell proliferation. Cell Cycle. 2012 Jul 15;11(14):2699-710 [3]. Kawabe Y，et al. The molecular mechanism of the induction of the low density lipoprotein receptor by chenodeoxycholic acid in cultured human cells. Biochem Biophys Res Commun. 1995 Mar 8;208(1):405-11. [4]. Ao M，et al. Chenodeoxycholic acid stimulates Cl(-) secretion via cAMP signaling and increases cystic fibrosis transmembrane conductance regulator phosphorylation in T84 cells. Am J Physiol Cell Physiol. 2013 Aug 15;305(4):C447-56 [5]. Noh K，et al. Farnesoid X receptor activation by chenodeoxycholic acid induces detoxifying enzymes through AMP-activated protein kinase and extracellular signal-regulated kinase 1/2-mediated phosphorylation of CCAAT/enhancer binding protein β. Drug Metab |
| Unit | Bottle |
| Specification | 50mg 10mM*1mL in DMSO 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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The polysaccharides from Auricularia auricula alleviate non-alcoholic fatty liver disease via modulating gut microbiota and bile acids metabolism
Click to check >>Author：Yifan Shu, Yujie Huang, Wei Dong, Xia Fan, Yi Sun, Guijie Chen, Xiaoxiong Zeng, Hong Ye
IF：8.2000
Publish_to：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
PMID：37399869
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