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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Neuronal Signal Pathway > Chlorpromazine HydrochlorideCAS：69-09-0
Molecular Formula：C17H19ClN2S·HCl
Molecular Weight：355.33
Storage：Powder:2-8℃，2 years
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 69-09-0 |
| Name | Chlorpromazine Hydrochloride |
| Molecular Formula | C17H19ClN2S·HCl |
| Molecular Weight | 355.33 |
| Solubility | Soluble in Water ≥10mg/mL(This product is not stable in solution, it is recommended that you use it now) |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years |
| EC | EINECS 200-701-3 |
| MDL | MFCD00012654 |
| SMILES | CN(C)CCCN1C2=C(C=CC=C2)SC3=CC=C(Cl)C=C13.Cl |
| InChIKey | FBSMERQALIEGJT-UHFFFAOYSA-N |
| InChI | InChI=1S/C17H19ClN2S.ClH/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20;/h3-4,6-9,12H,5,10-11H2,1-2H3;1H |
| PubChem CID | 6240 |
| Target Point | Dopamine Receptor; 5-HT Receptor; Sodium Channel; Potassium Channel |
| Passage | GPCR/G Protein; Neuronal Signaling; Membrane Transporter/Ion Channel |
| Background | It is an antagonist of D2, 5HT2A, potassium and sodium channels. It is also an intracellular inhibitor. |
| Biological Activity | Chlorpromazine Hydrochloride是D2，5HT2A，钾通道和钠通道的拮抗剂。 Chlorpromazine与 D2 和 5HT2A 结合的 Ki 分别为363 nM和8.3 nM。[1-5] |
| IC50 | Ki: 363nM(dopamine D2 receptor)，8.3nM(5-HT2A receptor)[4] |
| Data Literature Source | [1]. Lee SJ，et al. Mechanism of inhibition by chlorpromazine of the human pain threshold sodium channel，Nav1.7. Neurosci Lett. 2017 Feb 3;639:1-7 [2]. Kale OE，et al. Amlodipine，an L-type calcium channel blocker，protects against chlorpromazine-induced neurobehavioural deficits in mice. Fundam Clin Pharmacol. 2017 Jan 19 [3]. Sampaio LR，et al. Electroencephalographic study of chlorpromazine alone or combined with alpha-lipoic acid in a model of schizophrenia induced by ketamine in rats. J Psychiatr Res. 2017 Mar;86:73-82 [4]. Suzuki H，et al. Comparison of the anti-dopamine D and anti-serotonin 5-HT(2A) activities of chlorpromazine，bromperidol，haloperidol and second-generation antipsychotics parent compounds and metabolites thereof. J Psychopharmacol. 2013 Apr;27(4):396-400 [5]. Thomas，D.，et al. The antipsychotic drug chlorpromazine inhibits HERG potassium channels. Br J Pharmacol，2003. 139(3): p. 567-74. |
| Unit | Bottle |
| Specification | 10mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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