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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Endocrinology & Hormones > Clonidine HydrochlorideCAS：4205-91-8
Molecular Formula：C9H9Cl2N3·HCl
Molecular Weight：266.55
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 4205-91-8 |
| Name | Clonidine Hydrochloride |
| Molecular Formula | C9H9Cl2N3·HCl |
| Molecular Weight | 266.55 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 224-121-5 |
| MDL | MFCD00036705 |
| SMILES | ClC1=C(NC2=NCCN2)C(Cl)=CC=C1.Cl |
| InChIKey | ZNIFSRGNXRYGHF-UHFFFAOYSA-N |
| InChI | InChI=1S/C9H9Cl2N3.ClH/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9;/h1-3H,4-5H2,(H2,12,13,14);1H |
| PubChem CID | 20179 |
| Target Point | Adrenergic Receptor |
| Passage | Endocrinology & Hormones;GPCR & G Protein;Neuronal Signaling |
| Background | Clonidine hydrochloride is an α2-adrenoceptor agonist. |
| Biological Activity | Clonidine hydrochloride 是 α2-adrenoceptor 激动剂，为一种有效的抗高血压药。[1-4] |
| Data Literature Source | [1]. Bugajski J，et al. The involvement of central alpha-adrenergic and histamine H2-receptors in the hypothermia induced by clonidine in the rat. Neuropharmacology. 1980 Jan;19(1):9-15. [2]. Zhang YM，et al. Clonidine induces calcitonin gene-related peptide expression via nitric oxide pathway in endothelial cells. Peptides. 2009 Sep;30(9):1746-52. [3]. Jentsch JD，et al. Clonidine and guanfacine attenuate phencyclidine-induced dopamine overflow in rat prefrontal cortex: mediating influence of the alpha-2A adrenoceptor subtype. Brain Res. 2008 Dec 30;1246:41-6. [4]. Nassar N，et al. Brainstem adenosine A1 receptor signaling masks phosphorylated extracellular signal-regulated kinase 1/2-dependent hypotensive action of clonidine in conscious normotensive rats. J Pharmacol Exp Ther. 2009 Jan;328(1):83-9. |
| Unit | Bottle |
| Specification | 100mg 10mM*1mL in DMSO |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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