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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > CostunolideCAS：553-21-9
Molecular Formula：C15H20O2
Molecular Weight：232.32
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to yellow Solid
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| CAS | 553-21-9 |
| Name | Costunolide |
| Molecular Formula | C15H20O2 |
| Molecular Weight | 232.32 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | White to yellow Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00210262 |
| SMILES | O=C(O[C@@]1([H])[C@@]2([H])CC/C(C)=C/CC/C(C)=C/1)C2=C |
| InChIKey | HRYLQFBHBWLLLL-AHNJNIBGSA-N |
| InChI | InChI=1S/C15H20O2/c1-10-5-4-6-11(2)9-14-13(8-7-10)12(3)15(16)17-14/h5,9,13-14H,3-4,6-8H2,1-2H3/b10-5+,11-9+/t13-,14+/m0/s1 |
| PubChem CID | 5281437 |
| Target Point | Telomerase;FPTase;Apoptosis |
| Passage | Cell Cycle;DNA Damage/DNA Repair;Metabolic Enzyme&Protease;Apoptosis |
| Background | Costunolide is a sesquiterpene lactone with antioxidant, anti-inflammatory, anti-allergic, bone remodeling, neuroprotective, hair growth promotion, anti-cancer and anti-diabetic activities. Costunolide induces cell cycle arrest and apoptosis in breast cancer. |
| Biological Activity | Costunolide (NSC 106404)是一种天然倍半萜类化合物，具有多种生物活性；抑制FPTase，IC50为20 μM，也抑制telomerase（端粒酶），IC50为65-90 μM。[1] |
| Data Literature Source | [1] Choi SH，et al，Cancer Lett，2005，227(2)，153-162. [2] Park SH，et al，Planta Med，2001，67(4)，358-359. [3] Lee MG，et al，Biol Pharm Bull，2001，24(3)，303-306. [4] Duripandiyan V，et al，BMC Complement Altern Med，2012，12，13. [5] Jeong SJ，et al，Cancer Lett，2002，187(1-2)，129-133. |
| Unit | Bottle |
| Specification | 5mg 10mM*1mL in DMSO 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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