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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > JAK/STAT > CryptotanshinoneCAS：35825-57-1
Molecular Formula：C19H20O3
Molecular Weight：296.37
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：Orange Solid
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| CAS | 35825-57-1 |
| Name | Cryptotanshinone |
| Molecular Formula | C19H20O3 |
| Molecular Weight | 296.37 |
| Solubility | Soluble in DMSO ≥5mg/mL;Soluble in Ethanol ≥3mg/mL |
| Purity | HPLC≥98% |
| Appearance | Orange Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD07636810 |
| SMILES | O=C(C1=C2C=CC3=C1CCCC3(C)C)C(C4=C2OC[C@@H]4C)=O |
| InChIKey | GVKKJJOMQCNPGB-JTQLQIEISA-N |
| InChI | InChI=1S/C19H20O3/c1-10-9-22-18-12-6-7-13-11(5-4-8-19(13,2)3)15(12)17(21)16(20)14(10)18/h6-7,10H,4-5,8-9H2,1-3H3/t10-/m0/s1 |
| PubChem CID | 160254 |
| Target Point | STAT3 |
| Passage | JAK/STAT Signaling |
| Background | Cryptotanshinone can inhibit STAT3 and has antitumor activity. |
| Biological Activity | Cryptotanshinone是从丹参的根中提取的天然化合物, 具有抗肿瘤活性。 Cryptotanshinone抑制 STAT3 的 IC50 为4.6 μM[1-4]。 |
| IC50 | STAT3:4.6μM (IC50) [1-4] |
| Data Literature Source | [1]. Shin DS， et al. Cryptotanshinone inhibits constitutive signal transducer and activator of transcription 3 function through blocking the dimerization in DU145 prostate cancer cells. Cancer Res. 2009 Jan 1; 69 (1) :193-202. [2]. Huang Y， et al. Cryptotanshinone reverses ovarian insulin resistance in mice through activation of insulin signaling and the regulation of glucose transporters and hormone synthesizing enzymes. Fertil Steril. 2014 Aug; 102 (2) :589-596.e4. [3]. Ge Y， et al. Cryptotanshinone acts synergistically with imatinib to induce apoptosis of human chronic myeloid leukemia cells. Leuk Lymphoma. 2014 Jun 25:1-9. [4]. Kim EJ， et al. Antidiabetes and antiobesity effect of cryptotanshinone via activation of AMP-activated protein kinase. Mol Pharmacol. 2007 Jul; 72 (1) :62-72. Epub 2007 Apr 11. |
| Unit | Bottle |
| Specification | 10mg 10mM*1mL in DMSO 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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