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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > CytarabineCAS：147-94-4
Molecular Formula：C9H13N3O5
Molecular Weight：243.22
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 147-94-4 |
| Name | Cytarabine |
| Molecular Formula | C9H13N3O5 |
| Molecular Weight | 243.22 |
| Solubility | Soluble in Water ≥10mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 205-705-9 |
| MDL | MFCD00066487 |
| SMILES | O=C1N=C(N)C=CN1[C@H]2[C@H]([C@@H]([C@@H](CO)O2)O)O |
| InChIKey | UHDGCWIWMRVCDJ-CCXZUQQUSA-N |
| InChI | InChI=1S/C9H13N3O5/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)/t4-,6-,7+,8-/m1/s1 |
| PubChem CID | 6253 |
| Target Point | DNA/RNA Synthesis |
| Passage | Cell Cycle;DNA Damage/DNA Repair |
| Background | Cytarabine can interfere with cell proliferation by inhibiting cellular DNA synthesis. Cytarabine is the most sensitive to the effects of cells in the S phase proliferation phase, and has a weaker effect on inhibiting RNA and protein synthesis. |
| Biological Activity | Cytarabine是一种用于治疗急性髓性白血病的化疗药物，抑制DNA 合成的IC50为16 nM。[1-4] |
| Data Literature Source | [1]. Tobias，S.C. and R.F. Borch，Synthesis and biological evaluation of a cytarabine phosphoramidate prodrug. Mol Pharm，2004. 1(2): p. 112-6. [2]. Besirli，C.G.，et al. Cytosine arabinoside rapidly activates Bax-dependent apoptosis and a delayed Bax-independent death pathway in sympathetic neurons. Cell Death Differ，2003. 10(9): p. 1045-58. [3]. Yamauchi，H.，et al.，Involvement of p53 in 1-beta-D-arabinofuranosylcytosine-induced trophoblastic cell apoptosis and impaired proliferation in rat placenta. Biol Reprod，2004. 70(6): p. 1762-7. [4]. Richel，D.J.，et al.，Comparison of the antileukaemic activity of 5 aza-2-deoxycytidine and arabinofuranosyl-cytosine in rats with myelocytic leukaemia. Br J Cancer，1988. 58(6): p. 730-3 |
| Unit | Bottle |
| Specification | 50mg 10mM*1mL in Water 100mg 500mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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Li JJ, et al. Phytomedicine. 2023 Jan;109154605.
Li JJ, et al. Phytomedicine. 2023 Jan;109154605.
Gao Z, Li Z, Li X, Xiao J, Li C. Front Cell Dev Biol. 2023 Jun 1;11:1161541.
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Guiqi Baizhu prescription ameliorates cytarabine-induced intestinal mucositis by targeting JAK2 to inhibit M1 macrophage polarization
Click to check >>Author：Wei Chu; Ya-ling Li; Jun-jie Li; Jia Lin; Mi Li; J
IF：7.5000
Publish_to：BIOMEDICINE & PHARMACOTHERAPY
PMID：37209628
Guiqi Baizhu prescription ameliorates cytarabine-induced intestinal mucositis by targeting JAK2 to inhibit M1 macrophage polarization
Click to check >>Author：Wei Chu, Ya-ling Li, Jun-jie Li, Jia Lin, Mi Li, Jiao Wang, Jian-zheng He, Yue-mei Zhang, Juan Yao, Xiao-jie Jin, Hui Cai, Yong-qi Liu
IF：7.4190
Publish_to：BIOMEDICINE & PHARMACOTHERAPY
PMID：37209628
S100A16 suppresses the growth and survival of leukaemia cells and correlates with relapse and relapse free survival in adults with Philadelphia chromosome-negative B-cell acute lymphoblastic leukaemia
Click to check >>Author：Zhang J; Lu WY; Zhang JM; Lu RQ; Wu LX; Qin YZ; Li
IF：6.5000
Publish_to：Br J Haematol
PMID：30916375
Regulation of erythroid differentiation in K562 cells by the EPAS1-IRS2 axis under hypoxic conditions
Click to check >>Author：Gao Z; Li Z; Li X; Xiao J; Li C
IF：5.5000
Publish_to：Front Cell Dev Biol
PMID：37325570
Astragaloside IV alleviates cytarabine-induced intestinal mucositis by remodeling macrophage polarization through AKT signaling
Click to check >>Author：Li JJ. Li YL. Chu W. Li GQ. Zhang M. Dong JJ. Li L
IF：5.0370
Publish_to：Phytomedicine
PMID：36610133
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