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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Endocrinology & Hormones > DexamethasoneCAS：50-02-2
Molecular Formula：C22H29FO5
Molecular Weight：392.46
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
Qty：
Size：
| CAS | 50-02-2 |
| Name | Dexamethasone |
| Molecular Formula | C22H29FO5 |
| Molecular Weight | 392.46 |
| Solubility | Soluble in DMSO ≥50mg/mL;Soluble in Ethanol ≥5mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 200-003-9 |
| MDL | MFCD00064136 |
| SMILES | O=C1C=C[C@@]2(C)C(CC[C@]3([H])[C@]2(F)[C@@H](O)C[C@@]4(C)[C@@]3([H])C[C@@H](C)[C@@]4(C(CO)=O)O)=C1 |
| InChIKey | UREBDLICKHMUKA-CXSFZGCWSA-N |
| InChI | InChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1 |
| PubChem CID | 5743 |
| Target Point | Glucocorticoid Receptor (GR, or GCR);interleukin receptor |
| Passage | Endocrinology & Hormones;Immunology & Inflammation |
| Background | Dexamethasone is a glucocorticoid receptor agonist with anti-inflammatory and immunosuppressive effects. |
| Biological Activity | Dexamethasone 是一种糖皮质激素受体 (glucocorticoid receptor) 激动剂。Dexamethasone调节几种转录因子，包括激活蛋白-1，核因子-AT和核因子-κB，导致激活和抑制参与炎症反应的关键基因[1-5]。 |
| Data Literature Source | [1]. LaLone CA，et al. Effects of a glucocorticoid receptor agonist，Dexamethasone，on fathead minnow reproduction，growth，and development. Environ Toxicol Chem. 2012 Mar;31(3):611-22. [2]. Adcock IM，et al. Ligand-induced differentiation of glucocorticoid receptor (GR) trans-repression and transactivation: preferential targetting of NF-kappaB and lack of I-kappaB involvement. Br J Pharmacol. 1999 Jun;127(4):1003-11 [3]. Rocksén D，et al. Differential anti-inflammatory and anti-oxidative effects of Dexamethasone and N-acetylcysteine in endotoxin-induced lung inflammation. Clin Exp Immunol. 2000 Nov;122(2):249-56 [4]. Roussel D，et al. Dexamethasone treatment specifically increases the basal proton conductance of rat liver mitochondria. FEBS Lett. 2003 Apr 24;541(1-3):75-9. [5]. Maher HM，et al. Simultaneous determination of selected tyrosine kinase inhibitors with corticosteroids and antiemetics in rat plasma by solid phase extraction and ultra-performance liquid chromatography-tandem mass spectrometry: Application to pharmacokinetic interaction studies. J Pharm Biomed Anal. 2016 May 30;124:216-27. |
| Unit | Bottle |
| Specification | 100mg 10mM*1mL in DMSO 500mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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JWu, et al. European Journal of Pharmacology, 2019, 859:172484.
Shan H, et al. Cell Prolif. 2023 Apr 26:e13485.
Shan H, et al. Cell Prolif. 2023 Apr 26:e13485.
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能溶于水吗 2023-09-25 15:11:01
AdministratorDexamethasone地塞米松不溶于水。