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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > GPCR & G Protein > Dexamethasone AcetateCAS：1177-87-3
Molecular Formula：C24H31FO6
Molecular Weight：434.5
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 1177-87-3 |
| Name | Dexamethasone Acetate |
| Molecular Formula | C24H31FO6 |
| Molecular Weight | 434.5 |
| Solubility | Soluble in DMSO ≥10mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 214-646-8 |
| MDL | MFCD00027407 |
| SMILES | C[C@@]1([C@@]2(O)C(COC(C)=O)=O)[C@](C[C@H]2C)([H])[C@@](CCC3=CC4=O)([H])[C@@](F)([C@]3(C=C4)C)[C@@H](O)C1 |
| InChIKey | AKUJBENLRBOFTD-RPRRAYFGSA-N |
| InChI | InChI=1S/C24H31FO6/c1-13-9-18-17-6-5-15-10-16(27)7-8-21(15,3)23(17,25)19(28)11-22(18,4)24(13,30)20(29)12-31-14(2)26/h7-8,10,13,17-19,28,30H,5-6,9,11-12H2,1-4H3/t13-,17+,18+,19+,21+,22+,23+,24+/m1/s1 |
| PubChem CID | 236702 |
| Target Point | Glucocorticoid Receptor (GR, or GCR) |
| Passage | Immunology & Inflammation |
| Background | Dexamethasone Acetate is a glucocorticoid receptor agonist with anti-inflammatory and immunosuppressive activity. |
| Biological Activity | Dexamethasone是糖皮质素类甾体化合物，有抗炎和免疫抑制活性。[1-4] |
| Data Literature Source | [1]. LaLone CA，et al. Effects of a glucocorticoid receptor agonist，Dexamethasone，on fathead minnow reproduction，growth，and development. Environ Toxicol Chem. 2012 Mar;31(3):611-22. [2]. Adcock IM，et al. Ligand-induced differentiation of glucocorticoid receptor (GR) trans-repression and transactivation: preferential targetting of NF-kappaB and lack of I-kappaB involvement. Br J Pharmacol. 1999 Jun;127(4):1003-11 [3]. Rocksén D，et al. Differential anti-inflammatory and anti-oxidative effects of Dexamethasone and N-acetylcysteine in endotoxin-induced lung inflammation. Clin Exp Immunol. 2000 Nov;122(2):249-56 [4]. Roussel D，et al. Dexamethasone treatment specifically increases the basal proton conductance of rat liver mitochondria. FEBS Lett. 2003 Apr 24;541(1-3):75-9. |
| Unit | Bottle |
| Specification | 100mg 10mM*1mL in DMSO 500mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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