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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Endocrinology & Hormones > DHEACAS：53-43-0
Molecular Formula：C19H28O2
Molecular Weight：288.42
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 53-43-0 |
| Name | DHEA |
| Molecular Formula | C19H28O2 |
| Molecular Weight | 288.42 |
| Solubility | Soluble in DMSO ≥5mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 200-175-5 |
| MDL | MFCD00003613 |
| SMILES | O=C1CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C |
| InChIKey | FMGSKLZLMKYGDP-USOAJAOKSA-N |
| InChI | InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h3,13-16,20H,4-11H2,1-2H3/t13-,14-,15-,16-,18-,19-/m0/s1 |
| PubChem CID | 5881 |
| Target Point | Androgen Receptor |
| Passage | Endocrinology & Hormones |
| Background | DHEA is an important endogenous steroid hormone that can be used as an androgen receptor antagonist and an estrogen receptor agonist. |
| Biological Activity | DHEA是最丰富的类固醇激素之一。 DHEA通过多种信号传导途径介导其作用，并通过转化成雄激素和雌激素衍生物（例如，雄激素，雌激素，7α和7β DHEA，以及7α和7β表雄甾酮衍生物）通过其特异性受体起作用[1-3]。 |
| Data Literature Source | [1]. Anagnostopoulou V，et al. Differential effects of dehydroepiandrosterone and testosterone in prostate and colon cancer cell apoptosis: the role of nerve growth factor (NGF) receptors. Endocrinology. 2013 Jul;154(7):2446-56. [2]. McNelis JC，et al. Dehydroepiandrosterone exerts anti-glucocorticoid action on human preadipocyte proliferation，differentiation and glucose uptake. Am J Physiol Endocrinol Metab. 2013 Nov 1;305(9):E1134-44. [3]. Catalina F，et al. Decrease of core body temperature in mice by dehydroepiandrosterone. Exp Biol Med (Maywood). 2002 Jun;227(6):382-8. |
| Unit | Bottle |
| Specification | 10mg 10mM*1mL in DMSO 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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