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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Immunology & Inflammation > Diclofenac SodiumCAS：15307-79-6
Molecular Formula：C14H10Cl2NNaO2
Molecular Weight：318.13
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥99%
Appearance：White to off-white Solid
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| CAS | 15307-79-6 |
| Name | Diclofenac Sodium |
| Molecular Formula | C14H10Cl2NNaO2 |
| Molecular Weight | 318.13 |
| Solubility | Soluble in DMSO ≥3mg/mL;Soluble in Water ≥2mg/mL |
| Purity | HPLC≥99% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 239-346-4 |
| MDL | MFCD00082251 |
| SMILES | [O-]C(CC1=CC=CC=C1NC2=C(Cl)C=CC=C2Cl)=O.[Na+] |
| InChIKey | KPHWPUGNDIVLNH-UHFFFAOYSA-M |
| InChI | InChI=1S/C14H11Cl2NO2.Na/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19;/h1-7,17H,8H2,(H,18,19);/q;+1/p-1 |
| PubChem CID | 5018304 |
| Target Point | COX |
| Passage | Immunology & Inflammation |
| Background | Diclofenac Sodium is a potent, non-selective anti-inflammatory agent and inhibitor of COX. |
| Biological Activity | Diclofenac Sodium 是一种有效的，非选择性的抗炎剂，为 COX 的抑制剂，在 CHO 细胞中，对人 COX-1 和 COX-2 的 IC50 值分别为 4 nM，1.3 nM；Diclofenac Sodium 同时对绵羊 COX-1 和 COX-2 的 IC50 值分别为 5.1 μM，0.84 μM。[1-3] |
| Data Literature Source | [1]. Riendeau D，et al. Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor. Br J Pharmacol. 1997 May;121(1):105-17. [2]. Labib MB，et al. Design，synthesis of novel isoindoline hybrids as COX-2 inhibitors: Anti-inflammatory，analgesic activities and docking study. Bioorg Chem. 2018 Oct;80:70-80. [3]. Curcelli EC，et al. Beneficial effects of diclofenac therapy on serum lipids，oxidized low-density lipoprotein and antioxidant defenses in rats. Life Sci. 2008 Apr 9;82(15-16):892-8 |
| Unit | Bottle |
| Specification | 100mg 10mM*1mL in DMSO 500mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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Experimental investigation of the optimal driving pressure for a larger-volume controllable jet injection system
Click to check >>Author：Dongping Zeng, Zheng Tang, Wei Wang, Zefeng Wang, Jiamin Li
IF：2.2000
Publish_to：MEDICAL ENGINEERING & PHYSICS
PMID：37634910
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