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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > JAK/STAT > DiosgeninCAS：512-04-9
Molecular Formula：C27H42O3
Molecular Weight：414.63
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 512-04-9 |
| Name | Diosgenin |
| Molecular Formula | C27H42O3 |
| Molecular Weight | 414.63 |
| Solubility | Soluble in Ethanol ≥5mg/mL;Soluble in Water/DMSO ＜ 1 mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 208-134-3 |
| MDL | MFCD00016887 |
| SMILES | [C@@H]1(O)CC2[C@](C)(CC1)[C@]1([H])[C@]([H])([C@@]3([H])[C@@](CC1)(C)[C@@]1([H])[C@H](C)[C@]4(OC[C@H](C)CC4)O[C@@]1([H])C3)CC=2 |&1:0,4,8,10,12,14,18,20,22,25,30,r| |
| InChIKey | WQLVFSAGQJTQCK-VKROHFNGSA-N |
| InChI | InChI=1S/C27H42O3/c1-16-7-12-27(29-15-16)17(2)24-23(30-27)14-22-20-6-5-18-13-19(28)8-10-25(18,3)21(20)9-11-26(22,24)4/h5,16-17,19-24,28H,6-15H2,1-4H3/t16-,17+,19+,20-,21+,22+,23+,24+,25+,26+,27-/m1/s1 |
| PubChem CID | 99474 |
| Target Point | STAT;Pdia3/ERp57 |
| Passage | JAK/STAT Signaling;ER Stress |
| Background | It is a steroid saponin that can inhibit STAT3 signaling pathway. It is also an activator of Pdia3/ERp57. |
| Biological Activity | Diosgenin, a steroidal saponin, can inhibit STAT3 signaling pathway[1]. Diosgenin is an exogenous activator of Pdia3/ERp57[2]. |
| Data Literature Source | [1]. Li F，et al. Diosgenin，a steroidal saponin，inhibits STAT3 signaling pathway leading to suppression of proliferation and chemosensitization of human hepatocellular carcinoma cells. Cancer Lett. 2010 Jun 28;292(2):197-207. [2]. Tohda C，et al. Diosgenin is an exogenous activator of 1，25D -MARRS/Pdia3/ERp57 and improves Alzheimer's disease pathologies in 5XFAD mice. Sci Rep. 2012;2:535. [3]. Jeremy E. Chojnacki，et al. Bivalent ligands incorporating curcumin and diosgenin as multifunctional compounds against Alzheimer’s disease. Bioorganic & Medicinal Chemistry，23 (2015) 7324–7331 |
| Unit | Bottle |
| Specification | 10mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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Diosgenin alleviates the inflammatory damage and insulin resistance in high glucose?induced podocyte cells via the AMPK/SIRT1/NF?κB signaling pathway
Click to check >>Author：Haoyu Yuan, Huacheng Sui, Saimei Li
IF：2.7510
Publish_to：Experimental and Therapeutic Medicine
PMID：37153902
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