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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > DNA Damage & DNA Repai > Doxorubicin HydrochlorideCAS：25316-40-9
Molecular Formula：C27H29NO11·HCl
Molecular Weight：579.99
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：Orange to red Solid
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| CAS | 25316-40-9 |
| Name | Doxorubicin Hydrochloride |
| Molecular Formula | C27H29NO11·HCl |
| Molecular Weight | 579.99 |
| Solubility | Soluble in Water/DMSO |
| Purity | HPLC≥98% |
| Appearance | Orange to red Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 246-818-3 |
| MDL | MFCD00077757 |
| SMILES | COC1=C2C(C(C(C(O)=C(C[C@](C(CO)=O)(O)C[C@@H]3O[C@@]4([H])C[C@H](N)[C@H](O)[C@H](C)O4)C3=C5O)=C5C2=O)=O)=CC=C1.[H]Cl |
| InChIKey | MWWSFMDVAYGXBV-RUELKSSGSA-N |
| InChI | InChI=1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;1H/t10-,13-,15-,17-,22+,27-;/m0./s1 |
| PubChem CID | 443939 |
| Target Point | Topoisomerase |
| Passage | DNA Damage/DNA Repair |
| Background | It is a cytotoxic anthracycline antibiotic and is commonly used as a chemotherapy agent for cancer. It inhibits DNA replication by inhibiting topoisomerase-II. It can induce apoptosis and autophagy. |
| Biological Activity | Doxorubicin hydrochloride是一种有细胞毒性的蒽环类抗生素。 Doxorubicin 在癌细胞中起作用的可能机制是嵌入 DNA 和破坏 topoisomerase-II 介导的DNA修复。[1-4] |
| Data Literature Source | [1]. Nitiss JL， et al. Targeting DNA topoisomerase II in cancer chemotherapy.Nat Rev Cancer. 2009 May; 9 (5) :338-50. [2]. Sadeghi-Aliabadi H， et al. Cytotoxic evaluation of doxorubicin in combination with simvastatin against human cancer cells. Res Pharm Sci. 2010 Jul; 5 (2) :127-33. [3]. El-Zawahry A， et al. Doxorubicin increases the effectiveness of Apo2L/TRAIL for tumor growth inhibition of prostate cancerxenografts. BMC Cancer. 2005 Jan 7; 5:2. [4]. Hayward R， et al. Doxorubicin cardiotoxicity in the rat: an in vivo characterization. J Am Assoc Lab Anim Sci. 2007 Jul; 46 (4) :20-32 |
| Unit | Bottle |
| Specification | 10mg 10mM*1mL in DMSO 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Liu H, et al. Breast Cancer Res. 2023 Apr 17;25(1):43.
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