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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > Ellagic acidCAS：476-66-4
Molecular Formula：C14H6O8
Molecular Weight：302.19
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：Yellow to brown Solid
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| CAS | 476-66-4 |
| Name | Ellagic acid |
| Molecular Formula | C14H6O8 |
| Molecular Weight | 302.19 |
| Solubility | Soluble in DMSO ≥5mg/mL;Soluble in Ethanol <1mg/mL |
| Purity | HPLC≥98% |
| Appearance | Yellow to brown Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 207-508-3 |
| MDL | MFCD00006914 |
| SMILES | O=C1C2=CC(O)=C(O)C(O3)=C2C4=C(C3=O)C=C(O)C(O)=C4O1 |
| InChIKey | AFSDNFLWKVMVRB-UHFFFAOYSA-N |
| InChI | InChI=1S/C14H6O8/c15-5-1-3-7-8-4(14(20)22-11(7)9(5)17)2-6(16)10(18)12(8)21-13(3)19/h1-2,15-18H |
| PubChem CID | 5281855 |
| Target Point | Casein Kinase（CK） |
| Passage | Cell Cycle;DNA Damage/DNA Repair; Stem Cells |
| Background | Ellagic acid is an antioxidant and a potent, ATP-competitive inhibitor of CK2. |
| Biological Activity | Ellagic acid 是一种天然的抗氧化剂，为有效的，ATP 竞争性的 CK2 抑制剂，IC50 和 Ki 值分别为 40 nM 和 20 nM。[1-3] |
| Data Literature Source | [1]. Cozza G，et al. Identification of ellagic acid as potent inhibitor of protein kinase CK2: a successful example of a virtual screening application. J Med Chem. 2006 Apr 20;49(8):2363-6. [2]. Rizk HA，et al. Prophylactic effects of ellagic acid and rosmarinic acid on doxorubicin-induced neurotoxicity in rats. J Biochem Mol Toxicol. 2017 Dec;31(12). [3]. Ahire V，et al. Ellagic Acid Enhances Apoptotic Sensitivity of Breast Cancer Cells to γ-Radiation. Nutr Cancer. 2017 Aug-Sep;69(6):904-910. |
| Unit | Bottle |
| Specification | 10mg 10mM*1mL in DMSO 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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Lin Z, et al. Biomed Pharmacother. 2020 May;125:109845. doi: 10.1016/j.biopha.
Lin Z, et al. Biomed Pharmacother. 2020 May;125:109845. doi: 10.1016/j.biopha.
Lin Z, et al. Biomed Pharmacother. 2020 May;125:109845. doi: 10.1016/j.biopha.
Lin Z, et al. Biomed Pharmacother. 2020 May;125:109845. doi: 10.1016/j.biopha.
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The protective effect of Ellagic acid (EA) in osteoarthritis: An in vitro and in vivo study.
Click to check >>Author：Lin Z, Lin C, Fu C, Lu H, Jin H, Chen Q, Pan J.
IF：4.6960
Publish_to：Biomed Pharmacother.
PMID：32058211
Ellagic acid Alleviates hepatic ischemia–reperfusion injury in C57 mice via the Caspase-1-GSDMD pathway
Click to check >>Author：Wang H . Miao F . Ning D
IF：2.6700
Publish_to：BMC Veterinary Research
PMID：
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