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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Apoptosis > EmbelinCAS：550-24-3
Molecular Formula：C17H26O4
Molecular Weight：294.39
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：Yellow to brown Solid
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| CAS | 550-24-3 |
| Name | Embelin |
| Molecular Formula | C17H26O4 |
| Molecular Weight | 294.39 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | Yellow to brown Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 208-979-8 |
| MDL | MFCD00016369 |
| SMILES | O=C1C(O)=C(CCCCCCCCCCC)C(C(O)=C1)=O |
| InChIKey | IRSFLDGTOHBADP-UHFFFAOYSA-N |
| InChI | InChI=1S/C17H26O4/c1-2-3-4-5-6-7-8-9-10-11-13-16(20)14(18)12-15(19)17(13)21/h12,18,21H,2-11H2,1H3 |
| PubChem CID | 3218 |
| Target Point | XIAP |
| Passage | Apoptosis |
| Background | Embelin is a potent, non-peptide inhibitor of cellular permeability of XIAP. |
| Biological Activity | Embelin is a fairly potent, nonpeptidic, cell-permeable, small-molecule inhibitor of XIAP and represents a promising lead compound for designing an entirely new class of anticancer agents that target the BIR3 domain of XIAP.[1]Embelin is a novel NF-kappaB blocker and potential suppressor of tumorigenesis.[2] |
| Data Literature Source | [1]. Nikolovska-Coleska Z，Xu L，Hu Z，Tomita Y，Li P，Roller PP，Wang R，Fang X，Guo R，Zhang M，Lippman ME，Yang D，Wang S. Discovery of embelin as a cell-permeable，small-molecular weight inhibitor of XIAP through structure-based computational screening of a traditional herbal medicine three-dimensional structure database. J Med Chem. 2004 May 6;47(10):2430-40. [2]. Ahn KS，Sethi G，Aggarwal BB. Embelin，an inhibitor of X chromosome-linked inhibitor-of-apoptosis protein，blocks nuclear factor-kappaB (NF-kappaB) signaling pathway leading to suppression of NF-kappaB-regulated antiapoptotic and metastatic gene products. Mol Pharmacol. 2007 Jan;71(1):209-19. |
| Unit | Bottle |
| Specification | 10mg 10mM*1mL in DMSO 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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