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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Endocrinology & Hormones > EstradiolCAS：50-28-2
Molecular Formula：C18H24O2
Molecular Weight：272.39
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 50-28-2 |
| Name | Estradiol |
| Molecular Formula | C18H24O2 |
| Molecular Weight | 272.39 |
| Solubility | Soluble in DMSO ≥4mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 200-023-8 |
| MDL | MFCD00003693 |
| SMILES | C[C@@]1([C@H]2O)[C@](CC2)([H])[C@@](CCC3=C4C=CC(O)=C3)([H])[C@]4([H])CC1 |
| InChIKey | VOXZDWNPVJITMN-ZBRFXRBCSA-N |
| InChI | InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1 |
| PubChem CID | 5757 |
| Target Point | ERβ |
| Passage | Endocrinology & Hormones |
| Background | Estradiol is a steroid sex hormone. |
| Biological Activity | Estradiol 是一种类固醇性激素，对维持女性的生育能力和第二性征至关重要。雌二醇剂量依赖性地抑制IL-1，TNF-α和IL-1以及TNF诱导的生物可测定的IL-6的产生。[1-5] |
| Data Literature Source | [1]. Woolley CS，et al. Estradiol increases the sensitivity of hippocampal CA1 pyramidal cells to NMDA receptor-mediated synaptic input: correlation with dendritic spine density. J Neurosci. 1997 Mar 1;17(5):1848-59. [2]. Mermelstein PG，et al. Estradiol reduces calcium currents in rat neostriatal neurons via a membrane receptor. J Neurosci. 1996 Jan 15;16(2):595-604. [3]. Girasole G，et al. 17 beta-estradiol inhibits interleukin-6 production by bone marrow-derived stromal cells and osteoblasts in vitro: a potential mechanism for the antiosteoporotic effect of estrogens. J Clin Invest. 1992 Mar;89(3):883-91. [4]. Woolley CS，et al. Estradiol mediates fluctuation in hippocampal synapse density during the estrous cycle in the adult rat. J Neurosci. 1992 Jul;12(7):2549-54. [5]. Woolley CS，et al. Roles of estradiol and progesterone in regulation of hippocampal dendritic spine density during the estrous cycle in the rat. J Comp Neurol. 1993 Oct 8;336(2):293-306. |
| Unit | Bottle |
| Specification | 50mg 10mM*1mL in DMSO 100mg 200mg 500mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
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Zang L, et al. J Cell Mol Med. 2021 Jun;25(12)5753-5768.
Zang L, et al. J Cell Mol Med. 2021 Jun;25(12)5753-5768.
Zang L, et al. J Cell Mol Med. 2021 Jun;25(12)5753-5768.
Zang L, et al. J Cell Mol Med. 2021 Jun;25(12)5753-5768.
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