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Fenofibrate

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Cat.No：IF0040 Solarbio

CAS：49562-28-9

Molecular Formula：C₂₀H₂₁ClO₄

Molecular Weight：360.83

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥99%

Appearance：White to off-white Solid

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Product Information

CAS	49562-28-9
Name	Fenofibrate
Molecular Formula	C₂₀H₂₁ClO₄
Molecular Weight	360.83
Solubility	Soluble in DMSO ≥3.6mg/mL
Purity	≥99%
Appearance	White to off-white Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
EC	EINECS 256-376-3
MDL	MFCD00133314
SMILES	CC(C)(OC1=CC=C(C(C2=CC=C(Cl)C=C2)=O)C=C1)C(OC(C)C)=O
InChIKey	YMTINGFKWWXKFG-UHFFFAOYSA-N
InChI	InChI=1S/C20H21ClO4/c1-13(2)24-19(23)20(3,4)25-17-11-7-15(8-12-17)18(22)14-5-9-16(21)10-6-14/h5-13H,1-4H3
PubChem CID	3339
Target Point	PPAR;Cytochrome P450
Passage	Cell Cycle;DNA Damage/DNA Repair;Metabolic Enzyme&Protease
Background	Fenofibrate is a selective PPARα agonist. Fenofibrate inhibits cytochrome P450 isoforms such as CYP2C19, CYP2B6, CYP2C9, CYP2C8 and CYP3A4.
Biological Activity	Fenofibrate是 PPARα 激动剂，EC50 为30 μM。[1-2]
IC50	CYP2C19:0.2μM;CYP2B6:0.7μM [1]
Data Literature Source	[1]. Schelleman H，et al. Pharmacoepidemiologic and in vitro evaluation of potential drug-drug interactions of sulfonylureas with fibrates and statins. Br J Clin Pharmacol. 2014 Sep;78(3):639-48. [2]. Gong Y，et al. Fenofibrate Inhibits Cytochrome P450 Epoxygenase 2C Activity to Suppress Pathological Ocular Angiogenesis. EBioMedicine. 2016 Sep 30. pii: S2352-3964(16)30448-0.
Unit	Bottle
Specification	100mg 10mM*1mL in DMSO 500mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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