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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Apoptosis > Gambogic AcidCAS：2752-65-0
Molecular Formula：C38H44O8
Molecular Weight：628.75
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：Solid
Qty：
Size：
| CAS | 2752-65-0 |
| Name | Gambogic Acid |
| Molecular Formula | C38H44O8 |
| Molecular Weight | 628.75 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD16878985 |
| SMILES | O=C(O)/C(C)=C\C[C@@]1(C2=O)OC(C)(C)[C@@](C[C@@]2([H])C=C34)([H])[C@]31OC5=C(C(O)=C(C=C[C@](CC/C=C(C)/C)(C)O6)C6=C5C/C=C(C)\C)C4=O |
| InChIKey | GEZHEQNLKAOMCA-RRZNCOCZSA-N |
| InChI | InChI=1S/C38H44O8/c1-20(2)10-9-15-36(8)16-14-24-29(39)28-30(40)26-18-23-19-27-35(6,7)46-37(33(23)41,17-13-22(5)34(42)43)38(26,27)45-32(28)25(31(24)44-36)12-11-21(3)4/h10-11,13-14,16,18,23,27,39H,9,12,15,17,19H2,1-8H3,(H,42,43)/b22-13-/t23-,27+,36-,37+,38-/m1/s1 |
| PubChem CID | 9852185 |
| Target Point | Bcl-2 Family |
| Passage | Apoptosis |
| Background | It has been reported to inhibit Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1. |
| Biological Activity | Gambogic acid 来自 Garcinia hanburyi 树的藤黄树脂。Gambogic acid 抑制 Bcl-XL，Bcl-2，Bcl-W，Bcl-B，Bfl-1 和 Mcl-1，IC50 分别为 1.47 μM，1.21 μM，2.02 μM，0.66 μM，1.06 μM 和 0.79 μM。[1-2] |
| IC50 | Bcl-B:0.66μM;mcl-1:0.79μM;Bfl-1:1.06μM;Bcl-2:1.21μM;Bcl-xL:1.47μM;Bcl-W:2.02μM [1-2] |
| Data Literature Source | [1]. Zhai D，et al. Gambogic acid is an antagonist of antiapoptotic Bcl-2 family proteins. Mol Cancer Ther. 2008 Jun;7(6):1639-46. [2]. Wang LH，et al. Gambogic acid synergistically potentiates cisplatin-induced apoptosis in non-small-cell lung cancer through suppressing NF-κB and MAPK/HO-1 signalling. Br J Cancer. 2014 Jan 21;110(2):341-52 |
| Unit | Bottle |
| Specification | 5mg 10mg 20mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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