{{cart_num}}
My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Apoptosis > GossypolCAS：303-45-7
Molecular Formula：C30H30O8
Molecular Weight：518.55
Storage：Powder:2-8℃，2 years
Purity：HPLC≥98%
Appearance：Light yellow to yellow Solid
Qty：
Size：
| CAS | 303-45-7 |
| Name | Gossypol |
| Molecular Formula | C30H30O8 |
| Molecular Weight | 518.55 |
| Solubility | Soluble in DMSO ≥5mg/mL(This product is not stable in solution, it is recommended that you use it now) |
| Purity | HPLC≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years |
| EC | EINECS 636-899-7 |
| MDL | MFCD00017352 |
| SMILES | O=CC1=C(O)C(O)=C(C(C)C)C2=CC(C)=C(C3=C(C)C=C4C(C(C)C)=C(O)C(O)=C(C=O)C4=C3O)C(O)=C12 |
| InChIKey | QBKSWRVVCFFDOT-UHFFFAOYSA-N |
| InChI | InChI=1S/C30H30O8/c1-11(2)19-15-7-13(5)21(27(35)23(15)17(9-31)25(33)29(19)37)22-14(6)8-16-20(12(3)4)30(38)26(34)18(10-32)24(16)28(22)36/h7-12,33-38H,1-6H3 |
| PubChem CID | 3503 |
| Target Point | Bcl-2 Family;Bcl-xL |
| Passage | Apoptosis |
| Background | Gossypol is a potent inhibitor of 5 alpha-reductase 1 and 3 alpha-hydroxysteroid dehydrogenase. Gossypol also inhibits the binding of BH3 peptide to Bcl protein. |
| Biological Activity | Gossypol binds to Bcl-xL protein and Bcl-2 protein with Kis of 0.5-0.6 μM and 0.2-0.3 mM, respectively.[1]Gossypol inhibits 5α-reductase 1 and 3α-hydroxysteroid dehydrogenase: Its possible use for the treatment of prostate cancer[2] |
| Data Literature Source | [1]. Oliver CL，et al. In vitro effects of the BH3 mimetic，(-)-Gossypol，on head and neck squamous cell carcinoma cells. Clin Cancer Res. 2004 Nov 15;10(22):7757-63. |
| Unit | Bottle |
| Specification | 10mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Sorry, there is no more information.
Sorry, there is no more information.
Sorry, there is no more information.
Manual Download
