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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Protein Tyrosine Kinase/PTK > HarmineCAS：442-51-3
Molecular Formula：C13H12N2O
Molecular Weight：212.25
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：Off-white to brown Solid
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| CAS | 442-51-3 |
| Name | Harmine |
| Molecular Formula | C13H12N2O |
| Molecular Weight | 212.25 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | Off-white to brown Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 207-131-4 |
| MDL | MFCD00004958 |
| SMILES | CC1=NC=CC2=C1NC3=C2C=CC(OC)=C3 |
| InChIKey | BXNJHAXVSOCGBA-UHFFFAOYSA-N |
| InChI | InChI=1S/C13H12N2O/c1-8-13-11(5-6-14-8)10-4-3-9(16-2)7-12(10)15-13/h3-7,15H,1-2H3 |
| PubChem CID | 5280953 |
| Target Point | DYRK;PPARγ;5-HT Receptor;MAO-A |
| Passage | Cell Cycle;DNA Damage/DNA Repair;Metabolic Enzyme&Protease;Neuronal Signaling;GPCR & G Protein;Protein Tyrosine Kinase/RTK |
| Background | It is a bi-specific tyrosine phosphorylated regulated kinase (DYRK) inhibitor with anti-cancer and anti-inflammatory activities. It has a high affinity for 5-HT2A serotonin receptor. PPARγ expression is regulated by inhibition of Wnt signaling pathway. It also selectively binds MAO-A and reversibly inhibits it. |
| Biological Activity | Harmine是5-HT2A的抑制剂，Ki为397 nM [1]。 |
| Data Literature Source | [1]. Glennon RA，et al. Binding of beta-carbolines and related agents at serotonin (5-HT(2) and 5-HT(1A))，dopamine (D(2)) and benzodiazepine receptors. Drug Alcohol Depend. 2000 Aug 1;60(2):121-32. [2]. Neumann F，et al. DYRK1A inhibition and cognitive rescue in a Down syndrome mouse model are induced by new fluoro-DANDY derivatives. Sci Rep. 2018 Feb 12;8(1):2859. [3]. Zhang L，et al. Harmine suppresses homologous recombination repair and inhibits proliferation of hepatoma cells. Cancer Biol Ther. 2015;16(11):1585-92. [4]. Zhong Z，et al. Treatment with harmine ameliorates functional impairment and neuronal death following traumatic brain injury. Mol Med Rep. 2015 Dec;12(6):7985-91. |
| Unit | Bottle |
| Specification | 20mg 10mM*1mL in DMSO 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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