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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > PI3K/Akt/mTOR > HonokiolCAS：35354-74-6
Molecular Formula：C18H18O2
Molecular Weight：266.33
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 35354-74-6 |
| Name | Honokiol |
| Molecular Formula | C18H18O2 |
| Molecular Weight | 266.33 |
| Solubility | Soluble in DMSO ≥25mg/mL;Soluble in Ethanol ≥5mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 609-119-8 |
| MDL | MFCD00016674 |
| SMILES | OC1=C(CC=C)C=C(C2=CC(CC=C)=CC=C2O)C=C1 |
| InChIKey | FVYXIJYOAGAUQK-UHFFFAOYSA-N |
| InChI | InChI=1S/C18H18O2/c1-3-5-13-7-9-18(20)16(11-13)14-8-10-17(19)15(12-14)6-4-2/h3-4,7-12,19-20H,1-2,5-6H2 |
| PubChem CID | 72303 |
| Target Point | Akt |
| Passage | PI3K/Akt/mTOR |
| Background | Honokiol is a biologically active bisphenol-based phytochemical that targets multiple signaling molecules with potent antioxidant, anti-inflammatory, antiangiogenic and anticancer activities. It inhibits Akt activation and enhances ERK1/ERK2 phosphorylation. |
| Biological Activity | Honokiol是一种具有生物活性的双酚类植物化学物质，靶向多种信号分子，具有有效的抗氧化，抗炎，抗血管生成和抗癌活性。 它抑制 Akt 的活化并增强 ERK1/ERK2 的磷酸化。[1-4] |
| Data Literature Source | [1]. Chang KH，et al. Honokiol-induced apoptosis and autophagy in glioblastoma multiforme cells. Oncol Lett. 2013 Nov;6(5):1435-1438. [2]. Godugu C，et al. Honokiol nanomicellar formulation produced increased oral bioavailability and anticancer effects in triple negative breast cancer (TNBC). Colloids Surf B Biointerfaces. 2017 Jan 23;153:208-219 [3]. Lee TY，et al. Honokiol as a specific collagen receptor glycoprotein VI antagonist on human platelets: Functional ex vivo and in vivo studies. Sci Rep. 2017 Jan 5;7:40002 [4]. Zhai H，et al. Honokiol-induced neurite outgrowth promotion depends on activation of extracellular signal-regulated kinases (ERK1/2). Eur J Pharmacol. 2005 Jun 1;516(2):112-7. |
| Unit | Bottle |
| Specification | 10mg 10mM*1mL in DMSO 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
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Synthesis and bioactivity evaluation of novel nuciferine derivatives with antihyperuricemia and nephroprotective effects
Click to check >>Author：张玉凯
IF：5.2750
Publish_to：Bioorganic Chemistry
PMID：35687986
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