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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Endocrinology & Hormones > HydrocortisoneCAS：50-23-7
Molecular Formula：C21H30O5
Molecular Weight：362.46
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 50-23-7 |
| Name | Hydrocortisone |
| Molecular Formula | C21H30O5 |
| Molecular Weight | 362.46 |
| Solubility | Soluble in DMSO ≥5mg/mL;Soluble in Ethanol ≥10mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 200-020-1 |
| MDL | MFCD00011654 |
| SMILES | C[C@@]1([C@@]2(O)C(CO)=O)[C@](CC2)([H])[C@@](CCC3=CC4=O)([H])[C@]([C@]3(CC4)C)([H])[C@@H](O)C1 |
| InChIKey | JYGXADMDTFJGBT-VWUMJDOOSA-N |
| InChI | InChI=1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1 |
| PubChem CID | 5754 |
| Target Point | Glucocorticoid Receptor (GR, or GCR) |
| Passage | GPCR & G Protein |
| Background | Hydrocortisone is a glucocorticoid receptor agonist that promotes protein catabolism, gluconeogenesis, capillary wall stability, renal excretion of calcium, and suppresses immune and inflammatory responses. |
| Biological Activity | Hydrocortisone是肾上腺皮质分泌的类固醇激素或糖皮质激素。[1-3] |
| Data Literature Source | [1]. F rster C，et al. Differential effects of hydrocortisone and TNFalpha on tight junction proteins in an in vitro model of the human blood-brain barrier. J Physiol. 2008 Apr 1;586(7):1937-49. [2]. Bellinghausen I，et al. Inhibition of human allergic T-cell responses by IL-10-treated dendritic cells: differences from hydrocortisone-treated dendritic cells. J Allergy Clin Immunol. 2001 Aug;108(2):242-9. [3]. Chappell D，et al. Hydrocortisone preserves the vascular barrier by protecting the endothelial glycocalyx. Anesthesiology. 2007 Nov;107(5):776-84. |
| Unit | Bottle |
| Specification | 20mg 10mM*1mL in DMSO 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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IH0100和G8450有什么区别 2023-05-15 17:17:55
Administrator您好，纯度级别是不一样的，IH0100是HPLC法检测，纯度级别高一些