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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > DNA Damage & DNA Repai > (S)-10-HydroxycamptothecinCAS：19685-09-7
Molecular Formula：C20H16N2O5
Molecular Weight：364.35
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 19685-09-7 |
| Name | (S)-10-Hydroxycamptothecin |
| Molecular Formula | C20H16N2O5 |
| Molecular Weight | 364.35 |
| Solubility | Soluble in DMSO ≥10mg/mL |
| Purity | HPLC≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 805-668-4 |
| MDL | MFCD02093100 |
| SMILES | O=C1[C@](O)(CC)C2=C(CO1)C(N3CC4=CC5=CC(O)=CC=C5N=C4C3=C2)=O |
| InChIKey | HAWSQZCWOQZXHI-FQEVSTJZSA-N |
| InChI | InChI=1S/C20H16N2O5/c1-2-20(26)14-7-16-17-11(5-10-6-12(23)3-4-15(10)21-17)8-22(16)18(24)13(14)9-27-19(20)25/h3-7,23,26H,2,8-9H2,1H3/t20-/m0/s1 |
| PubChem CID | 97226 |
| Target Point | Topoisomerase |
| Passage | DNA Damage/DNA Repair |
| Background | (S)-10-Hydroxycamptothecin is a DNA topoisomerase I inhibitor. Can significantly induce apoptosis, and can be used for the study of liver cancer, gastric cancer, colon cancer and leukemia. |
| Biological Activity | (S)-10-Hydroxycamptothecin (10-HCPT;10-Hydroxycamptothecin) is a DNA topoisomerase I inhibitor of isolated from the Chinese plant Camptotheca accuminata. (S)-10-Hydroxycamptothecin exhibits a remarkable apoptosis-inducing effect. (S)-10-Hydroxycamptothecin has the potential for hepatoma， gastric carcinoma， colon cancer and leukaemia treatment[1-3]. |
| Data Literature Source | [1]. Min Liu，et al. Intracellular delivery of 10-hydroxycamptothecin with targeted nanostructured lipid carriers against multidrug resistance . Journal of Drug Targeting. [2]. Min Liu，et al. Intracellular delivery of 10-hydroxycamptothecin with targeted nanostructured lipid carriers against multidrug resistance. J Drug Target，Early Online: 1–8 [3]. Yu P，et al. Synthesis and preliminary anticancer evaluation of 10-hydroxycamptothecin analogs. Biol Pharm Bull. 2012;35(8):1295-9. |
| Unit | Bottle |
| Specification | 5mg 10mM*1mL in DMSO 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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