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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > HydroxyureaCAS：127-07-1
Molecular Formula：CH4N2O2
Molecular Weight：76.05
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 127-07-1 |
| Name | Hydroxyurea |
| Molecular Formula | CH4N2O2 |
| Molecular Weight | 76.05 |
| Solubility | Soluble in Water/DMSO |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 204-821-7 |
| MDL | MFCD00007943 |
| SMILES | O=C(N)NO |
| InChIKey | VSNHCAURESNICA-UHFFFAOYSA-N |
| InChI | InChI=1S/CH4N2O2/c2-1(4)3-5/h5H,(H3,2,3,4) |
| PubChem CID | 3657 |
| Target Point | DNA/RNA Synthesis |
| Passage | Cell Cycle;DNA Damage/DNA Repair |
| Background | Hydroxyurea is an apoptosis inducer that inhibits DNA synthesis by inhibiting ribonucleotide reductase. |
| Biological Activity | Hydroxyurea是通过抑制核糖核苷酸还原酶抑制DNA合成的细胞凋亡诱导剂。[1-4] |
| Data Literature Source | [1]. Kovacic P，et al. Hydroxyurea (therapeutics and mechanism): metabolism，carbamoyl nitroso，nitroxyl，radicals，cell signaling and clinical applications. Med Hypotheses. 2011 Jan;76(1):24-31. [2]. Watanapokasin Y，et al. In vivo and in vitro studies of fetal hemoglobin induction by hydroxyurea in beta-thalassemia/hemoglobin E patients. Exp Hematol. 2005 Dec;33(12):1486-92. [3]. Lori F，et al. Rationale for the use of hydroxyurea as an anti-human immunodeficiency virus drug. Clin Infect Dis. 2000 Jun;30 Suppl 2:S193-7. [4]. Lebensburger JD，et al. Hydroxyurea therapy requires HbF induction for clinical benefit in a sickle cell mouse model. Haematologica. 2010 Sep;95(9):1599-603. |
| Unit | Bottle |
| Specification | 50mg 100mg 10mM*1mL in DMSO |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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Hydroxyurea ameliorates atherosclerosis in ApoE-/- mice by potentially modulating Niemann-Pick C1-like 1 protein through the gut microbiota
Click to check >>Author：Yang XY; Yu H; Fu J; Guo HH; Han P; Ma SR; Pan LB;
IF：10.6680
Publish_to：Theranostics
PMID：36451858
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