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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Metabolic Enzyme & Protease > IBMXCAS：28822-58-4
Molecular Formula：C10H14N4O2
Molecular Weight：222.24
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥99%
Appearance：White to off-white Solid
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| CAS | 28822-58-4 |
| Name | IBMX |
| Molecular Formula | C10H14N4O2 |
| Molecular Weight | 222.24 |
| Solubility | Soluble in DMSO ≥10mg/mL;Soluble in Ethanol ≥10mg/mL |
| Purity | HPLC≥99% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 249-259-3 |
| MDL | MFCD00005584 |
| SMILES | O=C(N1C)N(CC(C)C)C2=C(N=CN2)C1=O |
| InChIKey | APIXJSLKIYYUKG-UHFFFAOYSA-N |
| InChI | InChI=1S/C10H14N4O2/c1-6(2)4-14-8-7(11-5-12-8)9(15)13(3)10(14)16/h5-6H,4H2,1-3H3,(H,11,12) |
| PubChem CID | 3758 |
| Target Point | Phosphodiesterase (PDE) |
| Passage | Metabolic Enzyme&Protease |
| Background | IBMX is a broad-spectrum, nonspecific phosphodiesterase (PDE) inhibitor. Can enhance intracellular cAMP levels, is an Adenosine (A1) receptor antagonist. Can inhibit the reduction of tryptamine induced by phenylephrine. |
| Biological Activity | IBMX 是一种广谱的磷酸二酯酶 (PDE) 抑制剂, 抑制 PDE3, PDE4 和 PDE5, IC50 分别为 6.5, 26.3 和 31.7 μM。[1] |
| IC50 | IC50: 6.5±1.2μM(PDE3) ， 26.3±3.9μM (PDE4) ， 31.7±5.3μM (PDE5) [1] |
| Data Literature Source | [1]. Wu BN， et al. KMUP-1， a xanthine derivative， induces relaxation of guinea-pig isolated trachea: the role of the epithelium， cyclic nucleotides and K+ channels. Br J Pharmacol. 2004 Aug; 142 (7) :1105-14 [2]. Wei Y， et al. Angiotensin II type 2 receptor regulates ROMK-like K+ channel activity in the renal cortical collecting duct during high dietary K+ adaptation. Am J Physiol Renal Physiol. 2014 Oct 1; 307 (7) :F833-43 [3]. Hosseini A， et al. Differential metabolic effects of novel cilostamide analogs， methyl carbostiryl derivatives， on mouse and hyperglycemic rat. Iran J Basic Med Sci. 2012 Jul; 15 (4) :916-25. [4]. Crosswhite P， et al. Inhibition of phosphodiesterase-1 attenuates cold-induced pulmonary hypertension. Hypertension. 2013 Mar; 61 (3) :585-92 |
| Unit | Bottle |
| Specification | 10mg 10mM*1mL in DMSO 50mg 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
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