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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Immunology & Inflammation > IbuprofenCAS：15687-27-1
Molecular Formula：C13H18O2
Molecular Weight：206.28
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 15687-27-1 |
| Name | Ibuprofen |
| Molecular Formula | C13H18O2 |
| Molecular Weight | 206.28 |
| Solubility | Soluble in DMSO/Ethanol ≥10mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 239-784-6 |
| MDL | MFCD00010393 |
| SMILES | OC(C(C1=CC=C(CC(C)C)C=C1)C)=O |
| InChIKey | HEFNNWSXXWATRW-UHFFFAOYSA-N |
| InChI | InChI=1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15) |
| PubChem CID | 3672 |
| Target Point | COX |
| Passage | Immunology & Inflammation |
| Background | I-BRD9 is a potent and selective BRD9 inhibitor. |
| Biological Activity | Ibuprofen 是 COX-1 和 COX-2 的抑制剂，IC50 值分别为 13 μM 和 370 μM，具有抗炎的活性。[1-5] |
| Data Literature Source | [1]. Noreen Y，et al. Development of a radiochemical cyclooxygenase-1 and -2 in vitro assay for identification of natural products as inhibitors of prostaglandin biosynthesis. J Nat Prod. 1998 Jan;61(1):2-7. [2]. Palayoor ST，et al. Constitutive activation of IkappaB kinase alpha and NF-kappaB in prostate cancer cells is inhibited by ibuprofen. Oncogene. 1999 Dec 2;18(51):7389-94. [3]. Khwaja F，et al. Ibuprofen inhibits survival of bladder cancer cells by induced expression of the p75NTR tumor suppressor protein. Cancer Res. 2004 Sep 1;64(17):6207-13. [4]. Rao GH，et al. Ibuprofen protects platelet cyclooxygenase from irreversible inhibition by aspirin. Arteriosclerosis. 1983 Jul-Aug;3(4):383-8. [5]. Driban JB，et al. Joint inflammation and early degeneration induced by high-force reaching are attenuated by ibuprofen in an animal model of work-related musculoskeletal disorder. J Biomed Biotechnol. 2011;2011:691412 |
| Unit | Bottle |
| Specification | 50mg 10mM*1mL in DMSO 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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Effect of ibuprofen on the sulfur autotrophic denitrification process and microbial toxic response mechanism
Click to check >>Author：Nengyao Xu, Haibo Li, Tingting Guo, Yanan Hou, Yi Han, Yuanyuan Song, Daohong Zhang, Jianbo Guo
IF：11.4000
Publish_to：BIORESOURCE TECHNOLOGY
PMID：37277006
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