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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > DNA Damage & DNA Repai > Irinotecan Hydrochloride TrihydrateCAS：136572-09-3
Molecular Formula：C33H38N4O6·HCl·3H2O
Molecular Weight：677.18
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 136572-09-3 |
| Name | Irinotecan Hydrochloride Trihydrate |
| Molecular Formula | C33H38N4O6·HCl·3H2O |
| Molecular Weight | 677.18 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 603-967-2 |
| MDL | MFCD01765731 |
| SMILES | [H]Cl.O=C(N1CCC(N2CCCCC2)CC1)OC3=CC=C4N=C5C(CN6C(C(COC([C@@]7(CC)O)=O)=C7C=C65)=O)=C(CC)C4=C3.O.O.O |
| InChIKey | KLEAIHJJLUAXIQ-JDRGBKBRSA-N |
| InChI | InChI=1S/C33H38N4O6.ClH.3H2O/c1-3-22-23-16-21(43-32(40)36-14-10-20(11-15-36)35-12-6-5-7-13-35)8-9-27(23)34-29-24(22)18-37-28(29)17-26-25(30(37)38)19-42-31(39)33(26,41)4-2;;;;/h8-9,16-17,20,41H,3-7,10-15,18-19H2,1-2H3;1H;3*1H2/t33-;;;;/m0..../s1 |
| PubChem CID | 60837 |
| Target Point | Topoisomerase |
| Passage | DNA Damage/DNA Repair |
| Background | Irinotecan hydrochloride trihydrate is a topoisomerase I (topoisomerase I) inhibitor with antitumor activity. |
| Biological Activity | Irinotecan hydrochloride trihydrate 是一种水溶性的topoisomerase I抑制剂，具有抗肿瘤活性。[1-3] |
| Data Literature Source | [1]. Morales C， et al. Antitumoral effect of irinotecan (CPT-11) on an experimental model of malignant neuroectodermal tumor. J Neurooncol. 2002 Feb; 56 (3) :219-26. [2]. Pavillard V， et al. Determinants of the cytotoxicity of irinotecan in two human colorectal tumor cell lines. Cancer Chemother Pharmacol. 2002 Apr; 49 (4) :329-35. Epub 2002 Jan 30. [3]. Allegrini G， et al. Thrombospondin-1 plus irinotecan: a novel antiangiogenic-chemotherapeutic combination that inhibits the growth of advanced human colon tumor xenografts in mice. Cancer Chemother Pharmacol. 2004 Mar; 53 (3) :261-6. Epub 2003 Dec 5. |
| Unit | Bottle |
| Specification | 10mg 10mM*1mL in DMSO 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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