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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > PI3K/Akt/mTOR > IsobavachalconeCAS：20784-50-3
Molecular Formula：C20H20O4
Molecular Weight：324.38
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 20784-50-3 |
| Name | Isobavachalcone |
| Molecular Formula | C20H20O4 |
| Molecular Weight | 324.38 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00902090 |
| SMILES | O=C(/C=C/C1=CC=C(C=C1)O)C2=CC=C(C(C/C=C(C)\C)=C2O)O |
| InChIKey | DUWPGRAKHMEPCM-IZZDOVSWSA-N |
| InChI | InChI=1S/C20H20O4/c1-13(2)3-9-16-19(23)12-10-17(20(16)24)18(22)11-6-14-4-7-15(21)8-5-14/h3-8,10-12,21,23-24H,9H2,1-2H3/b11-6+ |
| PubChem CID | 5281255 |
| Target Point | AKT |
| Passage | PI3K/Akt/mTOR |
| Background | It has been reported to induce apoptosis in neuroblastoma. |
| Biological Activity | Isobavachalcone (Corylifolinin) is derived from Psoralea corylifolia Linn. and is a potent inhibitor of Akt signaling pathway, which induces apoptosis in human cancer cells (Inhibits OVCAR-8 cell growth with an IC50 value of 7.92 μM). Isobavachalcone also induces Reactive Oxyen Species (ROS) generation in OVCAR-8 cells and has exhibit cancer anti-promotive and anti-proliferative activity[1]. |
| IC50 | 7.92μM(OVCAR-8 cell)[1] |
| Data Literature Source | [1]. Jing H，et al. Abrogation of Akt signaling by Isobavachalcone contributes to its anti-proliferative effects towards human cancer cells. Cancer Lett. 2010 Aug 28;294(2):167-77. |
| Unit | Bottle |
| Specification | 5mg 10mM*1mL in DMSO 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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