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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Metabolic Enzyme & Protease > IsoliquiritigeninCAS：961-29-5
Molecular Formula：C15H12O4
Molecular Weight：256.25
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 961-29-5 |
| Name | Isoliquiritigenin |
| Molecular Formula | C15H12O4 |
| Molecular Weight | 256.25 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 607-884-2 |
| MDL | MFCD00075907 |
| SMILES | O=C(C1=CC=C(O)C=C1O)/C=C/C2=CC=C(O)C=C2 |
| InChIKey | DXDRHHKMWQZJHT-FPYGCLRLSA-N |
| InChI | InChI=1S/C15H12O4/c16-11-4-1-10(2-5-11)3-8-14(18)13-7-6-12(17)9-15(13)19/h1-9,16-17,19H/b8-3+ |
| PubChem CID | 638278 |
| Target Point | Aldose Reductase |
| Passage | Metabolic Enzyme&Protease |
| Background | Isoliquiritigenin is a flavonoid with antitumor activity that inhibits the activity of aldose reductase. |
| Biological Activity | Isoliquiritigenin 是从光果甘草根中分到的黄酮类化合物, 具有抗肿瘤的活性, 能够抑制 aldose reductase 的活性, IC50 值为 320 nM[1-4]。 |
| IC50 | IC50: 320nM (Aldose reductase) [1-4] |
| Data Literature Source | [1]. Aida K， et al. Isoliquiritigenin: a new aldose reductase inhibitor from glycyrrhizae radix. Planta Med. 1990 Jun; 56 (3) :254-8. [2]. Sato Y， et al. Isoliquiritigenin， one of the antispasmodic principles of Glycyrrhiza ularensis roots， acts in the lower part of intestine. Biol Pharm Bull. 2007 Jan; 30 (1) :145-9. [3]. Zhang X. Natural antioxidant-isoliquiritigenin ameliorates contractile dysfunction of hypoxic cardiomyocytes via AMPK signaling pathway. Mediators Inflamm. 2013; 2013:390890. [4]. Chen X， et al. Isoliquiritigenin inhibits the growth of multiple myeloma via blocking IL-6 signaling. J Mol Med (Berl) . 2012 Nov; 90 (11) :1311-9. |
| Unit | Bottle |
| Specification | 10mg 10mM*1mL in DMSO 20mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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