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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Others > Licochalcone ACAS：58749-22-7
Molecular Formula：C21H22O4
Molecular Weight：338.4
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：Solid
Qty：
Size：
| CAS | 58749-22-7 |
| Name | Licochalcone A |
| Molecular Formula | C21H22O4 |
| Molecular Weight | 338.4 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 635-678-2 |
| MDL | MFCD01417903 |
| SMILES | O=C(C1=CC=C(O)C=C1)/C=C/C2=CC(C(C)(C)C=C)=C(O)C=C2OC |
| InChIKey | KAZSKMJFUPEHHW-DHZHZOJOSA-N |
| InChI | InChI=1S/C21H22O4/c1-5-21(2,3)17-12-15(20(25-4)13-19(17)24)8-11-18(23)14-6-9-16(22)10-7-14/h5-13,22,24H,1H2,2-4H3/b11-8+ |
| PubChem CID | 5318998 |
| Passage | Others |
| Background | It is a flavonoid with anticancer, antibacterial and antiviral activities. |
| IC50 | Licochalcone A，an oxygenated chalcone isolated from the roots of Chinese licorice plant，inhibited the growth of both Leishmaniamajor and Leishmania donovani promastigotes and amastigotes. [2]The vegetative cell growth of Bacillus subtilis was inhibited in a licochalcone A concentration-dependentmanner and was completely prevented by 3micrograms of licochalcone A/ml. Licochalcone A showed a high level of resistance to heating at 80 to 121 degrees C for 15min. Licochalcone A didnot inhibit the germination of heat-treated spores of B. subtilis induced by L-alanine. Licochalcone A showed effects against all gram-positive bacteria tested and especially was effective against all Bacillus spp.[3] |
| Data Literature Source | [1]. Chen M，Christensen SB，Theander TG，Kharazmi A. Antileishmanial activity of licochalcone A in mice infected with Leishmania major and in hamsters infected with Leishmania donovani. Antimicrob Agents Chemother. 1994 Jun;38(6):1339-44. [2]. Chen M，Christensen SB，Blom J，Lemmich E，Nadelmann L，Fich K，Theander TG，Kharazmi A. Licochalcone A，a novel antiparasitic agent with potent activity against human pathogenic protozoan species of Leishmania. Antimicrob Agents Chemother. 1993 Dec;37(12):2550-6. [3]. Tsukiyama R，Katsura H，Tokuriki N，Kobayashi M. Antibacterial activity of licochalcone A against spore-forming bacteria. Antimicrob Agents Chemother. 2002 May;46(5):1226-30. |
| Unit | Bottle |
| Specification | 5mg 10mM*1mL in DMSO 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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