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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Metabolic Enzyme & Protease > MagnololCAS：528-43-8
Molecular Formula：C18H18O2
Molecular Weight：266.33
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 528-43-8 |
| Name | Magnolol |
| Molecular Formula | C18H18O2 |
| Molecular Weight | 266.33 |
| Solubility | Soluble in DMSO ≥10mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 610-903-7 |
| MDL | MFCD00016658 |
| SMILES | OC1=CC=C(CC=C)C=C1C2=CC(CC=C)=CC=C2O |
| InChIKey | VVOAZFWZEDHOOU-UHFFFAOYSA-N |
| InChI | InChI=1S/C18H18O2/c1-3-5-13-7-9-17(19)15(11-13)16-12-14(6-4-2)8-10-18(16)20/h3-4,7-12,19-20H,1-2,5-6H2 |
| PubChem CID | 72300 |
| Target Point | RAR/RXR;PPAR |
| Passage | Cell Cycle;DNA Damage/DNA Repair;Metabolic Enzyme&Protease |
| Background | It is a dual agonist of RXRα and PPARγ. |
| Biological Activity | Magnolol 是从厚朴的树皮中分到的木脂素，为 RXRα 和 PPARγ 的双重激动剂，EC50 值分别为 10.4 μM 和 17.7 μM。[1-3] |
| IC50 | RXRα:10.4μM(EC50);PPARγ:17.7μM(EC50)[1-3] |
| Data Literature Source | [1]. Zhang H，et al. Molecular determinants of magnolol targeting both RXRα and PPARγ. PLoS One. 2011;6(11):e28253. [2]. Choi SS，et al. Magnolol enhances adipocyte differentiation and glucose uptake in 3T3-L1 cells. Life Sci. 2009 Jun 19;84(25-26):908-14. [3]. Zhao L，et al. Magnolol，a Natural Polyphenol，Attenuates Dextran Sulfate Sodium-Induced Colitis in Mice. Molecules. 2017 Jul 20;22(7). pii: E1218. |
| Unit | Bottle |
| Specification | 10mg 10mM*1mL in DMSO 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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