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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > GPCR & G Protein > MelatoninCAS：73-31-4
Molecular Formula：C13H16N2O2
Molecular Weight：232.28
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥95%
Appearance：White to off-white Solid
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| CAS | 73-31-4 |
| Name | Melatonin |
| Molecular Formula | C13H16N2O2 |
| Molecular Weight | 232.28 |
| Solubility | Soluble in DMSO ≥3mg/mL;Soluble in Ethanol ≥50mg/mL |
| Purity | HPLC≥95% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 200-797-7 |
| MDL | MFCD00005655 |
| SMILES | CC(NCCC1=CNC2=C1C=C(OC)C=C2)=O |
| InChIKey | DRLFMBDRBRZALE-UHFFFAOYSA-N |
| InChI | InChI=1S/C13H16N2O2/c1-9(16)14-6-5-10-8-15-13-4-3-11(17-2)7-12(10)13/h3-4,7-8,15H,5-6H2,1-2H3,(H,14,16) |
| PubChem CID | 896 |
| Target Point | Melatonin Receptor(MT Receptor);ATF-6 |
| Passage | GPCR & G Protein;Neuronal Signaling;ER Stress |
| Background | Melatonin is a hormone that activates melatonin receptors and plays a role in sleep. Melatonin is also a novel and selective ATF-6 inhibitor. |
| Biological Activity | Melatonin是一种由松果体制成的激素，可激活褪黑激素受体。 Melatonin在睡眠中起作用并具有重要的抗氧化和抗炎特性。[1-3] |
| Data Literature Source | [1]. Kilic U，et al. Particular phosphorylation of PI3K/Akt on Thr308 via PDK-1 and PTEN mediates melatonin's neuroprotective activity after focal cerebral ischemia in mice. Redox Biol. 2017 Apr 5;12:657-665 [2]. Hu C，et al. Neuroprotective effect of melatonin on soluble Aβ1-42-induced cortical neurodegeneration via Reelin-Dab1 signaling pathway. Neurol Res. 2017 Apr 7:1-1 [3]. Rahim I，et al. Melatonin administration to wild-type mice and non-treated NLRP3 mutant mice share similar inhibition of the inflammatory response during sepsis. J Pineal Res. 2017 Mar 31 |
| Unit | Bottle |
| Specification | 20mg 10mM*1mL in DMSO 50mg 500mg 1g 5g |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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Melatonin enhances KCl salinity tolerance by maintaining K+ homeostasis in Malus hupehensis
Click to check >>Author：Zhijuan Sun, Jianyu Li, Dianming Guo, Tianchao Wang, Yike Tian, Changqing Ma, Xiaoli Liu, Caihong Wang, Xiaodong Zheng
IF：13.8000
Publish_to：PLANT BIOTECHNOLOGY JOURNAL
PMID：37465981
Melatonin modulates the hypothalamic-pituitary neuroendocrine axis to regulate physiological color change in teleost fish
Click to check >>Author：Jiaqian Feng; Jingwen Yang; Zhijing Jiang; Naiming
IF：9.2000
Publish_to：International Journal of Biological Sciences
PMID：37324950
Integrated enzymes activity and transcriptome reveal the effect of exogenous melatonin on the strain degeneration of Cordyceps militaris
Click to check >>Author：Zhichao Zu, Siqi Wang, Yingming Zhao, Wenli Fan, Tianlai Li
IF：6.0640
Publish_to：Frontiers in Microbiology
PMID：37089574
Integrated enzymes activity and transcriptome reveal the effect of exogenous melatonin on the strain degeneration of Cordyceps militaris
Click to check >>Author：Zhichao Zu; Siqi Wang; Yingming Zhao; Wenli Fan; T
IF：5.2000
Publish_to：Frontiers in Microbiology
PMID：37089574
Effects of melatonin and Trichoderma harzianum on pak choi yield,chlorophyll contents and antioxidant defense system under clubroot disease
Click to check >>Author：Shazma Gulzar, Muhammad Aamir Manzoor, Fiza Liaquat, Iftikhar Hussain Shah, Asad Rehman, Muhammad Khalid Hameed, Samiah Arif, Xuanwei Zhou, Yidong Zhang
IF：3.1110
Publish_to：SOUTH AFRICAN JOURNAL OF BOTANY
PMID：
Melatonin induces resistance against Penicillium expansum in apple fruit through enhancing phenylpropanoid metabolism
Click to check >>Author：Miao Wang, Yihan Li, Canying Li, Hengping Xu, Tong Sun, Yonghong Ge
IF：2.7000
Publish_to：PHYSIOLOGICAL AND MOLECULAR PLANT PATHOLOGY
PMID：
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