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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Immunology & Inflammation > MeloxicamCAS：71125-38-7
Molecular Formula：C14H13N3O4S2
Molecular Weight：351.4
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：Solid
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| CAS | 71125-38-7 |
| Name | Meloxicam |
| Molecular Formula | C14H13N3O4S2 |
| Molecular Weight | 351.4 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 615-253-8 |
| MDL | MFCD11046047 |
| SMILES | O=C(C1=C(O)C2=CC=CC=C2S(N1C)(=O)=O)NC3=NC=C(C)S3 |
| InChIKey | ZRVUJXDFFKFLMG-UHFFFAOYSA-N |
| InChI | InChI=1S/C14H13N3O4S2/c1-8-7-15-14(22-8)16-13(19)11-12(18)9-5-3-4-6-10(9)23(20,21)17(11)2/h3-7,18H,1-2H3,(H,15,16,19) |
| PubChem CID | 54677470 |
| Target Point | COX |
| Passage | Immunology & Inflammation |
| Background | Meloxicam is a non-steroidal anti-inflammatory agent that effectively inhibits the activity of COX. |
| Biological Activity | Meloxicam 是一种非甾体类抗炎剂，能够有效抑制 COX 的活性，对 COX-2 和 COX-1 的 IC50 值分别为 0.49 μM 和 36.6 μM。[1-3] |
| IC50 | COX-2:0.49μM;COX-1:36.6μM [1-3] |
| Data Literature Source | [1]. Lazer ES，et al. Effect of structural modification of enol-carboxamide-type nonsteroidal antiinflammatory drugs on COX-2/COX-1 selectivity. J Med Chem. 1997 Mar 14;40(6):980-9. [2]. Iturriaga MP，et al. Meloxicam decreases the migration and invasion of CF41.Mg canine mammary carcinoma cells. Oncol Lett. 2017 Aug;14(2):2198-2206. [3]. Fikry EM，et al. Rutin and meloxicam attenuate paw inflammation in mice: Affecting sorbitol dehydrogenase activity. J Biochem Mol Toxicol. 2018 Feb;32(2) |
| Unit | Bottle |
| Specification | 50mg 10mM*1mL in DMSO 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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Meloxicam Improves Cognitive Impairment of Diabetic Rats through COX2-PGE2-EPs-cAMP/pPKA Pathway
Click to check >>Author：Li H; Luo Y; Xu Y; Yang L; Hu C; Chen Q; Yang Y; M
IF：4.9000
Publish_to：MOL PHARMACEUT
PMID：30109938
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