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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > PI3K/Akt/mTOR > Metformin HydrochlorideCAS：1115-70-4
Molecular Formula：C4H12ClN5
Molecular Weight：165.63
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 1115-70-4 |
| Name | Metformin Hydrochloride |
| Molecular Formula | C4H12ClN5 |
| Molecular Weight | 165.63 |
| Solubility | Soluble in Water ≥5mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 214-230-6 |
| MDL | MFCD00012582 |
| SMILES | NC(NC(N(C)C)=N)=N.Cl |
| InChIKey | OETHQSJEHLVLGH-UHFFFAOYSA-N |
| InChI | InChI=1S/C4H11N5.ClH/c1-9(2)4(7)8-3(5)6;/h1-2H3,(H5,5,6,7,8);1H |
| PubChem CID | 14219 |
| Target Point | AMPK |
| Passage | PI3K/Akt/mTOR;Epigenetics |
| Background | Metformin inhibits the mitochondrial respiratory chain in the liver, leading to AMPK activation and enhanced insulin sensitivity, which can be used in the study of type 2 diabetes mellitus. It can also cross the blood-brain barrier and induce autophagy. |
| Biological Activity | 二甲双胍主要是通过对线粒体呼吸链复合物1的轻度和短暂抑制降低肝脏葡萄糖的产生。[1-7] |
| Data Literature Source | [1]. Soraya H，et al. Acute treatment with metformin improves cardiac function following isoproterenol induced myocardial infarction in rats. Pharmacol Rep. 2012;64(6):1476-84. [2]. Quaile MP，et al. Toxicity and toxicokinetics of metformin in rats. Toxicol Appl Pharmacol. 2010 Mar 15;243(3):340-7. [3]. Xue J，et al. Metformin inhibits growth of eutopic stromal cells from adenomyotic endometrium via AMPK activation and subsequent inhibition of AKT phosphorylation: a possible role in the treatment of adenomyosis. Reproduction. 2013 Aug 21;146(4):397-406. [4]. Otto M，et al. Metformin inhibits glycogen synthesis and gluconeogenesis in cultured rat hepatocytes. Diabetes Obes Metab. 2003 May;5(3):189-94. [5]. Avci CB，et al. Therapeutic potential of an anti-diabetic drug，metformin: alteration of miRNA expression in prostate cancer cells. Asian Pac J Cancer Prev. 2013;14(2):765-8. [6]. Nie L，et al. The Landscape of Histone Modifications in a High-Fat Diet-Induced Obese (DIO) Mouse Model. Mol Cell Proteomics. 2017 Jul;16(7):1324-1334. [7]. Zhang D，et al. Metformin ameliorates BSCB disruption by inhibiting neutrophil infiltration and MMP-9 expression but not direct TJ proteins expression regulation. J Cell Mol Med. 2017 Jul 12. |
| Unit | Bottle |
| Specification | 100mg 10mM*1mL in Water 500mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Yao Y, et al. Phytomedicine. 2020 Oct;77:153268.
Jia L, Xiong Y, Zhang W, Ma X, Xu X. Metformin promotes osteogenic differentiation and protects against oxidative stress-induced damage in periodontal ligament stem cells via activation of the Akt/Nrf2 signaling pathway. Exp Cell Res. 2020 Jan 15;386(2):111717. doi: 10.1016/j.yexcr.2019.111717. Epub 2019 Nov 9. PMID: 31715142.
Zhong QW, et al. Food Chem. 2021 Mar 30;341(Pt 1):128148.
Jia L, Xiong Y, Zhang W, Ma X, Xu X. Metformin promotes osteogenic differentiation and protects against oxidative stress-induced damage in periodontal ligament stem cells via activation of the Akt/Nrf2 signaling pathway. Exp Cell Res. 2020 Jan 15;386(2):111717. doi: 10.1016/j.yexcr.2019.111717. Epub 2019 Nov 9. PMID: 31715142.
Jia L, Xiong Y, Zhang W, Ma X, Xu X. Metformin promotes osteogenic differentiation and protects against oxidative stress-induced damage in periodontal ligament stem cells via activation of the Akt/Nrf2 signaling pathway. Exp Cell Res. 2020 Jan 15;386(2):111717. doi: 10.1016/j.yexcr.2019.111717. Epub 2019 Nov 9. PMID: 31715142.
Lja B, et al. Experimental cell research, 386(2):111717.
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