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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Metabolic Enzyme & Protease > MethotrexateCAS：1959/5/2
Molecular Formula：C20H22N8O5
Molecular Weight：454.44
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥99%
Appearance：Yellow Solid
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| CAS | 1959/5/2 |
| Name | Methotrexate |
| Molecular Formula | C20H22N8O5 |
| Molecular Weight | 454.44 |
| Solubility | Soluble in DMSO ≥30mg/mL |
| Purity | ≥99% |
| Appearance | Yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 200-413-8 |
| MDL | MFCD00064370 |
| SMILES | NC1=NC(N)=C2C(N=CC(CN(C)C3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)=N2)=N1 |
| InChIKey | FBOZXECLQNJBKD-ZDUSSCGKSA-N |
| InChI | InChI=1S/C20H22N8O5/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27)/t13-/m0/s1 |
| PubChem CID | 126941 |
| Target Point | Antifolate;DHFR |
| Passage | Cell Cycle;DNA Damage/DNA Repair;Metabolic Enzyme&Protease; |
| Background | Methotrexate is a folate antagonist that inhibits dihydrofolate reductase, thereby preventing the conversion of folate to tetrahydrofolate and inhibiting DNA synthesis. |
| Biological Activity | Methotrexate是一种叶酸拮抗剂，在体外试验中 IC50 为 78 nM。[1-2] |
| Data Literature Source | [1]. Norris RE，et al. Clinical potency of methotrexate，aminopterin，talotrexin and pemetrexed in childhood leukemias. Cancer Chemother Pharmacol. 2010 May;65(6):1125-30. [2]. Gu S，et al. Screening of cytoprotectors against methotrexate-induced cytogenotoxicity from bioactive phytochemicals. PeerJ. 2016 May 11;4:e1983 |
| Unit | Bottle |
| Specification | 50mg 10mM*1mL in DMSO 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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