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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > PI3K/Akt/mTOR > 3-MethyladenineCAS：5142-23-4
Molecular Formula：C6H7N5
Molecular Weight：149.15
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥97%
Appearance：White to off-white Solid
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| CAS | 5142-23-4 |
| Name | 3-Methyladenine |
| Molecular Formula | C6H7N5 |
| Molecular Weight | 149.15 |
| Solubility | Soluble in DMSO/DMF ≥10mg/mL |
| Purity | ≥97% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 225-908-6 |
| MDL | MFCD00010531 |
| SMILES | NC1=C2N=CN=C2N(C)C=N1 |
| InChIKey | ZPBYVFQJHWLTFB-UHFFFAOYSA-N |
| InChI | InChI=1S/C6H7N5/c1-11-3-10-5(7)4-6(11)9-2-8-4/h2-3,7H,1H3,(H,8,9) |
| PubChem CID | 135398661 |
| Target Point | PI3K; Autophagy |
| Passage | PI3K/Akt/mTOR; Autophagy |
| Background | It is a selective PI3K inhibitor that acts on Vps34 and PI3Kγ, and is also an autophagy inhibitor. |
| Biological Activity | 3-Methyladenine是 PI3K 的抑制剂。它通过抑制class III PI3K广泛作为自噬 (autophagy) 的抑制剂使用[1-4]。 |
| IC50 | PtdIns3Kγ:60μM (IC50， Cell Assay) Vps34:25μM (IC50， Cell Assay) [1-4] |
| Data Literature Source | [1]. Miller S， et al. Finding a fitting shoe for Cinderella: searching for an autophagy inhibitor. Autophagy. 2010 Aug; 6 (6) :805-807. [2]. Hou H， et al. Inhibitors of phosphatidylinositol 3'-kinases promote mitotic cell death in HeLa cells. PLoS One. 2012; 7 (4) :e35665. [3]. Wang X， et al. Acanthopanax versus 3-Methyladenine Ameliorates Sodium Taurocholate-Induced Severe Acute Pancreatitis by Inhibiting the Autophagic Pathway in Rats. Mediators Inflamm. 2016; 2016:8369704. [4]. Meng Li， et al. Alda-1 Ameliorates Liver Ischemia-Reperfusion Injury by Activating Aldehyde Dehydrogenase 2 and Enhancing Autophagy in Mice. J Immunol Res. 7 August 2018. |
| Unit | Bottle |
| Specification | 10mg 20mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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Liu J Z, et al. Journal of Experimental & Clinical Cancer Research, 2020, 39(1).
Li C, et al. Arch Pharm Res. 2020 Aug;43(8):863-874.
Dang H, et al. Sci Rep. 2023 Jan 28;13(1):1574.
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