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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Immunology & Inflammation > NaproxenCAS：22204-53-1
Molecular Formula：C14H14O3
Molecular Weight：230.26
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 22204-53-1 |
| Name | Naproxen |
| Molecular Formula | C14H14O3 |
| Molecular Weight | 230.26 |
| Solubility | Soluble in DMSO ≥20mg/mL;Soluble in Water ＜ 1mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 244-838-7 |
| MDL | MFCD00010500 |
| SMILES | C[C@H](C(O)=O)C1=CC2=CC=C(OC)C=C2C=C1 |
| InChIKey | CMWTZPSULFXXJA-VIFPVBQESA-N |
| InChI | InChI=1S/C14H14O3/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10/h3-9H,1-2H3,(H,15,16)/t9-/m0/s1 |
| PubChem CID | 156391 |
| Target Point | COX |
| Passage | Immunology & Inflammation |
| Background | Naproxen is an inhibitor of COX-1 and COX-2. |
| Biological Activity | Naproxen是COX-1 和 COX-2 的抑制剂，在细胞试验中 IC50 值分别为8.72 和5.15 μM[1-3]. |
| IC50 | COX-2:5.65μM;COX-1:9.55μM [1-3] |
| Data Literature Source | [1]. Mitchell JA，et al. Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11693-7. [2]. Rosa AC，et al. Prevention of bleomycin-induced lung inflammation and fibrosis in mice by naproxen and JNJ7777120 treatment. J Pharmacol Exp Ther. 2014 Nov;351(2):308-16. [3]. Krekels EH，et al. Pharmacokinetic-pharmacodynamic modeling of the inhibitory effects of naproxen on the time-courses of inflammatory pain，fever，and the ex vivo synthesis of TXB2 and PGE2 in rats. |
| Unit | Bottle |
| Specification | 100mg 10mM*1mL in DMSO 500mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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A Multichannel Fluorescent Array Sensor for Discrimination of Different Types of Drug-Induced Kidney Injury
Click to check >>Author：Kunhui Sun, Bing Wang, Jiaoli Lin, Lei Han, Meifang Li, Ping Wang, Xiean Yu, Jiangwei Tian
IF：3.9000
Publish_to：SENSORS
PMID：37447963
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