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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Metabolic Enzyme & Protease > NaringinCAS：10236-47-2
Molecular Formula：C27H32O14
Molecular Weight：580.53
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to yellow Solid
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| CAS | 10236-47-2 |
| Name | Naringin |
| Molecular Formula | C27H32O14 |
| Molecular Weight | 580.53 |
| Solubility | Soluble in DMSO ≥10mg/mL;Soluble in Ethanol ≥5mg/mL;Soluble in Water < 1mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 233-566-4 |
| MDL | MFCD00148888 |
| SMILES | O=C1C[C@@H](C2=CC=C(O)C=C2)OC3=CC(O[C@H]4[C@@H]([C@H]([C@@H]([C@@H](CO)O4)O)O)O[C@@]5([H])[C@@H]([C@@H]([C@H]([C@H](C)O5)O)O)O)=CC(O)=C13 |
| InChIKey | DFPMSGMNTNDNHN-ZPHOTFPESA-N |
| InChI | InChI=1S/C27H32O14/c1-10-20(32)22(34)24(36)26(37-10)41-25-23(35)21(33)18(9-28)40-27(25)38-13-6-14(30)19-15(31)8-16(39-17(19)7-13)11-2-4-12(29)5-3-11/h2-7,10,16,18,20-30,32-36H,8-9H2,1H3/t10-,16-,18+,20-,21+,22+,23-,24+,25+,26-,27+/m0/s1 |
| PubChem CID | 442428 |
| Target Point | Cytochrome P450 |
| Passage | Metabolic Enzyme&Protease |
| Background | Naringin is a flavanone glycoside with many biological activities, which can be used for researches on antioxidant activity, blood lipid lowering, anticancer, and inhibition of cytochrome P450 enzymes. |
| Biological Activity | Naringin是黄烷酮糖苷, 有很多药理作用, 例如抗氧化活性, 降血脂, 抗癌, 抑制细胞色素P450酶[1-4]。 |
| IC50 | IC50: 9026 uM(p450) [1-4] |
| Data Literature Source | [1]. Chen F， et al. Naringin Alleviates Diabetic Kidney Disease through Inhibiting Oxidative Stress and Inflammatory Reaction. PLoS One. 2015 Nov 30; 10 (11) :e0143868. [2]. Raha S， et al. Naringin induces autophagy-mediated growth inhibition by downregulating the PI3K/Akt/mTOR cascade via activation of MAPK pathways in AGS cancer cells. Int J Oncol. 2015 Sep; 47 (3) :1061-9. [3]. Kulasekaran G， et al. Neuroprotective efficacy of naringin on 3-nitropropionic acid-induced mitochondrial dysfunction through the modulation of Nrf2 signaling pathway in PC12 cells. Mol Cell Biochem. 2015 Nov; 409 (1-2) :199-211. [4]. Wang D， et al. Naringin Improves Neuronal Insulin Signaling， Brain Mitochondrial Function， and Cognitive Function in High-Fat Diet-Induced Obese Mice. Cell Mol Neurobiol. 2015 Oct; 35 (7) :1061-71 |
| Unit | Bottle |
| Specification | 10mg 10mM*1mL in DMSO 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
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