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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Membrane Transporter & Ion Channel > NonivamideCAS：2444-46-4
Molecular Formula：C17H27NO3
Molecular Weight：293.4
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 2444-46-4 |
| Name | Nonivamide |
| Molecular Formula | C17H27NO3 |
| Molecular Weight | 293.4 |
| Solubility | Soluble in DMSO ≥10mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 219-484-1 |
| MDL | MFCD00017286 |
| SMILES | CCCCCCCCC(NCC1=CC=C(O)C(OC)=C1)=O |
| InChIKey | RGOVYLWUIBMPGK-UHFFFAOYSA-N |
| InChI | InChI=1S/C17H27NO3/c1-3-4-5-6-7-8-9-17(20)18-13-14-10-11-15(19)16(12-14)21-2/h10-12,19H,3-9,13H2,1-2H3,(H,18,20) |
| PubChem CID | 2998 |
| Target Point | TRPV1 |
| Passage | Membrane Transporter&Ion Channel;Neuronal Signaling |
| Background | Nonivamide is a TRPV1 agonist. |
| Biological Activity | TRPV1 agonist (nonivamide) treatment caused calcium release from the ER and altered the transcription of growth arrest- and DNA damage-inducible transcript 3 (GADD153)， GADD45alpha， GRP78/BiP， ATF3， CCND1， and CCNG2) in a manner comparable with prototypical ER stress-inducing agents.[1] |
| Data Literature Source | [1]. Thomas KC，Sabnis AS，Johansen ME，Lanza DL，Moos PJ，Yost GS，Reilly CA. Transient receptor potential vanilloid 1 agonists cause endoplasmic reticulum stress and cell death in human lung cells. J Pharmacol Exp Ther. 2007 Jun;321(3):830-8. doi: 10.1124/jpet.107.119412. Epub 2007 Mar 1. PMID: 17332266. |
| Unit | Bottle |
| Specification | 10mg 10mM*1mL in DMSO 50mg 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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