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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > GPCR & G Protein > OstholeCAS：484-12-8
Molecular Formula：C15H16O3
Molecular Weight：244.29
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 484-12-8 |
| Name | Osthole |
| Molecular Formula | C15H16O3 |
| Molecular Weight | 244.29 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 1532714-185-1 |
| MDL | MFCD00076049 |
| SMILES | O=C1C=CC2=CC=C(OC)C(C/C=C(C)\C)=C2O1 |
| InChIKey | MBRLOUHOWLUMFF-UHFFFAOYSA-N |
| InChI | InChI=1S/C15H16O3/c1-10(2)4-7-12-13(17-3)8-5-11-6-9-14(16)18-15(11)12/h4-6,8-9H,7H2,1-3H3 |
| PubChem CID | 10228 |
| Target Point | Histamine Receptor |
| Passage | GPCR & G Protein;Neuronal Signaling;Immunology & Inflammation |
| Background | It effectively inhibits histamine H1 receptor activity. |
| Biological Activity | Osthole 可有效抑制组胺 H1 受体 (histamine H1 receptor) 活性[1-3]。 |
| Data Literature Source | [1]. Kordulewska NK， et al. Changes in gene expression induced by histamine， fexofenadine and osthole: Expression of histamine H1 receptor， COX-2， NF-κB， CCR1， chemokine CCL5/RANTES and interleukin-1β in PBMC allergic and non-allergic patients. Immunobiology. [2]. Tang DZ， et al. Osthole stimulates osteoblast differentiation and bone formation by activation of beta-catenin-BMP signaling. J Bone Miner Res. 2010 Jun; 25 (6) :1234-45. [3]. Sun W， et al. Osthole pretreatment alleviates TNBS-induced colitis in mice via both cAMP/PKA-dependent and independent pathways. Acta Pharmacol Sin. 2017 Aug; 38 (8) :1120-1128 |
| Unit | Bottle |
| Specification | 20mg 10mM*1mL in DMSO 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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The neuroprotective effect of osthole against chronic sleep deprivation (CSD)-induced memory impairment in rats
Click to check >>Author：Tang H. Li K. Dou X. Zhao Y. Huang C. Shu F
IF：4.6590
Publish_to：Life Sci
PMID：33011218
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