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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > Pemetrexed DisodiumCAS：357166-30-4
Molecular Formula：2(C20H19N5Na2O6)·5(H2O)
Molecular Weight：1032.84
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 357166-30-4 |
| Name | Pemetrexed Disodium |
| Molecular Formula | 2(C20H19N5Na2O6)·5(H2O) |
| Molecular Weight | 1032.84 |
| Solubility | Soluble in Water |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD08458870 |
| SMILES | O=C([O-])CC[C@@H](C([O-])=O)NC(C1=CC=C(CCC2=CNC(N=C(N)N3)=C2C3=O)C=C1)=O.[Na+].[2.5H2O].[Na+] |
| InChIKey | ZCTCZKWJFTYNMZ-WKUCUCPSSA-J |
| InChI | InChI=1S/2C20H21N5O6.4Na.5H2O/c2*21-20-24-16-15(18(29)25-20)12(9-22-16)6-3-10-1-4-11(5-2-10)17(28)23-13(19(30)31)7-8-14(26)27;;;;;;;;;/h2*1-2,4-5,9,13H,3,6-8H2,(H,23,28)(H,26,27)(H,30,31)(H4,21,22,24,25,29);;;;;5*1H2/q;;4*+1;;;;;/p-4/t2*13-;;;;;;;;;/m00........./s1 |
| PubChem CID | 135564527 |
| Target Point | Antifolate |
| Passage | Cell Cycle;DNA Damage/DNA Repair |
| Background | Pemetrexed Disodium is a folic acid antagonist. Inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR) and glycinamide nucleotide formyltransferase (GARFT). |
| Biological Activity | Pemetrexed disodium hemipenta hydrate 是一种叶酸拮抗剂 (antifolate)。抑制胸苷酸合成酶 (TS)，二氢叶酸还原酶 (DHFR) 和甘氨酰胺核苷酸甲酰转移酶 (GARFT)，Ki 分别为 1.3 nM，7.2 nM 和 65 nM。[1-2] |
| IC50 | Ki: 1.3nM(TS)，7.2nM(DHFR)，65nM(GARFT)[1] |
| Data Literature Source | [1]. Shih C，et al. LY231514，a pyrrolo[2，3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes. Cancer Res. 1997 Mar 15;57(6):1116-23. [2]. Anraku M，et al. Synergistic antitumor effects of regulatory T cell blockade combined with pemetrexed in murine malignantmesothelioma. J Immunol. 2010 Jul 15;185(2):956-66. |
| Unit | Bottle |
| Specification | 10mg 10mM*1mL in Water 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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