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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Membrane Transporter & Ion Channel > ProbenecidCAS：57-66-9
Molecular Formula：C13H19NO4S
Molecular Weight：285.36
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 57-66-9 |
| Name | Probenecid |
| Molecular Formula | C13H19NO4S |
| Molecular Weight | 285.36 |
| Solubility | Soluble in DMSO ≥10mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 200-344-3 |
| MDL | MFCD00038402 |
| SMILES | O=C(O)C1=CC=C(S(=O)(N(CCC)CCC)=O)C=C1 |
| InChIKey | DBABZHXKTCFAPX-UHFFFAOYSA-N |
| InChI | InChI=1S/C13H19NO4S/c1-3-9-14(10-4-2)19(17,18)12-7-5-11(6-8-12)13(15)16/h5-8H,3-4,9-10H2,1-2H3,(H,15,16) |
| PubChem CID | 4911 |
| Target Point | TRP Channel |
| Passage | Membrane Transporter&Ion Channel;Neuronal Signaling |
| Background | Prim-O-glucosylcimifugin has strong anti-inflammatory activity and can inhibit the expression of iNOS and COX-2 by regulating JAK2/STAT3 signaling. |
| Biological Activity | Probenecid 是一种有效的选择性瞬时受体电位香草酸受体通道 2 (TRPV2) 激动剂。[1-3] |
| Data Literature Source | [1]. Koch SE，et al. Probenecid: novel use as a non-injurious positive inotrope acting via cardiac TRPV2 stimulation. J Mol Cell Cardiol. 2012 Jul;53(1):134-44. [2]. Bakos E，et al. Interactions of the human multidrug resistance proteins MRP1 and MRP2 with organic anions. Mol Pharmacol. 2000 Apr;57(4):760-8. [3]. Greene TA，et al. Probenecid inhibits the human bitter taste receptor TAS2R16 and suppresses bitter perception of salicin. PLoS One. 2011;6(5):e20123. |
| Unit | Bottle |
| Specification | 100mg 10mM*1mL in DMSO 500mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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Unusual Flavones from Primula macrocalyx as Inhibitors of OAT1 and OAT3 and as Antifungal Agents against Candida rugosa
Click to check >>Author：Li X; Wang X; Li C; Khutsishvili M; Fayvush G; Ath
IF：4.6000
Publish_to：Sci Rep
PMID：31239507
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