| CAS |
30636-90-9 |
| Chinese Name |
原人参二醇 |
| English Name |
(20S)-Protopanaxadiol |
| Synonyms |
20(S-APPD）;20-Epiprotopanaxadiol;20 (S-原人参二醇;(20S-Protopanaxadiol） |
| Molecular Formula |
C30H52O3 |
| Molecular Weight |
460.74 |
| Solubility |
Soluble in DMSO |
| Purity |
HPLC≥98% |
| Appearance |
White to off-white Solid |
| Storage |
Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL |
MFCD12032048 |
| SMILES |
C[C@]([C@@](C[C@H]1O)([H])[C@]2(CC[C@@H]3O)C)(CC[C@@]2([H])C3(C)C)[C@]4([C@@]1([H])[C@]([C@@](C)(O)CC/C=C(C)/C)([H])CC4)C |
| InChIKey |
PYXFVCFISTUSOO-HKUCOEKDSA-N |
| InChI |
InChI=1S/C30H52O3/c1-19(2)10-9-14-30(8,33)20-11-16-29(7)25(20)21(31)18-23-27(5)15-13-24(32)26(3,4)22(27)12-17-28(23,29)6/h10,20-25,31-33H,9,11-18H2,1-8H3/t20-,21+,22-,23+,24-,25-,27-,28+,29+,30-/m0/s1 |
| PubChem CID |
11213350 |
| Target Point |
P-gp(P-glycoprotein);Apoptosis |
| Passage |
Membrane Transporter&Ion Channel |
| Background |
It is an aglycone metabolic derivative of protopanaxadiol ginsenoside and is an apoptosis inducer. |
| Biological Activity |
20S-protopapanaxadiol (aglycone PPD, aPPD) , unlike its precursor ginsenosides Rg3 and Rh2, is not a substrate of P-gp. It is also the first time that aPPD has showed a reversible nature of its P-gp inhibition. In addition to its pro-apoptotic nature, aPPD may be a potential new P-gp inhibitor for cancer treatment.[1] |
| In Vitro |
20S-protopapanaxadiol(aglycone PPD，aPPD)caused similar cytotoxicity in P388adr cells as their parental non-MDR cells，suggesting that aPPD may not be a substrate of P-gp. On the other hand，the calcein AM efflux assay showed that aPPD was able to inhibit P-gp activity as potently as verapamil on MDR cells. The blockage of P-gp activity was highly reversible as wash-out of aPPD resulted in an immediate recovery of P-gp activity. Unlike verapamil，aPPD did not affect ATPase activity of P-gp suggesting a different mechanism of action.[1] |
| Data Literature Source |
[1]. Zhao Y，Bu L，Yan H，Jia W. 20S-protopanaxadiol inhibits P-glycoprotein in multidrug resistant cancer cells. Planta Med. 2009 Aug;75(10):1124-8. |
| Unit |
Bottle |
| Specification |
10mg 10mM*1mL in DMSO 20mg |
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