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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Membrane Transporter & Ion Channel > (20S)-ProtopanaxadiolCAS：30636-90-9
Molecular Formula：C30H52O3
Molecular Weight：460.74
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 30636-90-9 |
| Name | (20S)-Protopanaxadiol |
| Molecular Formula | C30H52O3 |
| Molecular Weight | 460.74 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD12032048 |
| SMILES | C[C@]([C@@](C[C@H]1O)([H])[C@]2(CC[C@@H]3O)C)(CC[C@@]2([H])C3(C)C)[C@]4([C@@]1([H])[C@]([C@@](C)(O)CC/C=C(C)/C)([H])CC4)C |
| InChIKey | PYXFVCFISTUSOO-HKUCOEKDSA-N |
| InChI | InChI=1S/C30H52O3/c1-19(2)10-9-14-30(8,33)20-11-16-29(7)25(20)21(31)18-23-27(5)15-13-24(32)26(3,4)22(27)12-17-28(23,29)6/h10,20-25,31-33H,9,11-18H2,1-8H3/t20-,21+,22-,23+,24-,25-,27-,28+,29+,30-/m0/s1 |
| PubChem CID | 11213350 |
| Target Point | P-gp(P-glycoprotein);Apoptosis |
| Passage | Membrane Transporter&Ion Channel |
| Background | It is an aglycone metabolic derivative of protopanaxadiol ginsenoside and is an apoptosis inducer. |
| Biological Activity | 20S-protopapanaxadiol (aglycone PPD, aPPD) , unlike its precursor ginsenosides Rg3 and Rh2, is not a substrate of P-gp. It is also the first time that aPPD has showed a reversible nature of its P-gp inhibition. In addition to its pro-apoptotic nature, aPPD may be a potential new P-gp inhibitor for cancer treatment.[1] |
| Data Literature Source | [1]. Zhao Y，Bu L，Yan H，Jia W. 20S-protopanaxadiol inhibits P-glycoprotein in multidrug resistant cancer cells. Planta Med. 2009 Aug;75(10):1124-8. |
| Unit | Bottle |
| Specification | 10mg 10mM*1mL in DMSO 20mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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