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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > NF-κB > ResveratrolCAS：501-36-0
Molecular Formula：C14H12O3
Molecular Weight：228.24
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 501-36-0 |
| Name | Resveratrol |
| Molecular Formula | C14H12O3 |
| Molecular Weight | 228.24 |
| Solubility | Soluble in DMSO/Ethanol ≥10mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 610-504-8 |
| MDL | MFCD00133799 |
| SMILES | OC1=CC=C(/C=C/C2=CC(O)=CC(O)=C2)C=C1 |
| InChIKey | LUKBXSAWLPMMSZ-OWOJBTEDSA-N |
| InChI | InChI=1S/C14H12O3/c15-12-5-3-10(4-6-12)1-2-11-7-13(16)9-14(17)8-11/h1-9,15-17H/b2-1+ |
| PubChem CID | 445154 |
| Target Point | Sirtuin;PXR;Nrf2;IKKβ; Autophagy; Mitophagy;mTOR;Amyloid-β |
| Passage | Epigenetics;NF-κB; Autophagy;PI3K/Akt/mTOR;Neuronal Signaling |
| Background | Resveratrol is a polyphenolic plant antitoxin with antioxidant， anti-inflammatory， heart-protecting and anticancer activities. Resveratrol targets a wide range of targets， such as mTOR， JAK， β-amyloid， COX， LOC， Nrf2， PXR， etc. Resveratrol is also a specific SIRT1 activator. |
| Biological Activity | Resveratrol (SRT 501) 是一种天然多酚，具有抗氧化，抗炎，保护心脏和抗癌的特性。 它的靶点广泛，如 mTOR，JAK，β-amyloid。Resveratrol也是一种sirtuin活化剂。[1-3] |
| Data Literature Source | [1]. Pirola L，et al. Resveratrol: one molecule，many targets. IUBMB Life. 2008 May;60(5):323-32 [2]. Lu R，et al. Resveratrol，a natural product derived from grape，exhibits antiestrogenic activity and inhibits the growth of human breast cancer cells. J Cell Physiol. 1999 Jun;179(3):297-304. [3]. Lee MH，et al. Resveratrol suppresses growth of human ovarian cancer cells in culture and in a murine xenograft model: eukaryotic elongation factor 1A2 as a potential target. Cancer Res. 2009 Sep 15;69(18):7449-58. [4]. LI Ying，et al. Prevention of resveratrol on spatial memory loss of mice induced by calyculin A. Chin J Pathophysiol，2017，33(5): 951-955. |
| Unit | Bottle |
| Specification | 20mg 10mM*1mL in DMSO 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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Wu L, et al. Front Immunol. 2023 Apr 24;14:1177140.
Wu L, et al. Front Immunol. 2023 Apr 24;14:1177140.
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Resveratrol alleviates lipopolysaccharide-induced liver injury by inducing SIRT1/P62-mediated mitophagy in gibel carp (Carassius gibelio)
Click to check >>Author：Liyun Wu, Qiaozhen Chen, Bo Dong, Hancheng Geng, Yu Wang, Dong Han, Xiaoming Zhu, Haokun Liu, Zhimin Zhang, Yunxia Yang, Shouqi Xie, Junyan Jin
IF：8.7860
Publish_to：Frontiers in Immunology
PMID：37168854
Resveratrol alleviates lipopolysaccharide-induced liver injury by inducing SIRT1/P62-mediated mitophagy in gibel carp (Carassius gibelio)
Click to check >>Author：Wu L; Chen Q; Dong B; Geng H; Wang Y; Han D; Zhu X
IF：7.3000
Publish_to：Front Immunol
PMID：37168854
Protective effect and possible mechanisms of resveratrol in animal models of osteoporosis: A preclinical systematic review and meta-analysis
Click to check >>Author：Fan Lin, Jiaru Chen, Mangmang Chen, Shenglei Lin, Shuangxia Dong
IF：7.2000
Publish_to：PHYTOTHERAPY RESEARCH
PMID：37482965
Identification of microRNAs implicated in modulating resveratrol-induced apoptosis in porcine granulosa cells
Click to check >>Author：Huibin Zhang, Jinglin Wang, Fan Xie, Yangguang Liu, Mengyao Qiu, Zheng Han, Yueyun Ding, Xianrui Zheng, Zongjun Yin, Xiaodong Zhang
IF：6.0810
Publish_to：Frontiers in Cell and Developmental Biology
PMID：37250898
Identification of microRNAs implicated in modulating resveratrol-induced apoptosis in porcine granulosa cells
Click to check >>Author：Zhang H; Wang J; Xie F; Liu Y; Qiu M; Han Z; Ding Y; Zheng X; Yin Z; Zhang X.
IF：5.5000
Publish_to：Frontiers in Cell and Developmental Biology
PMID：37250898
Resveratrol inhibits autophagy against myocardial ischemia-reperfusion injury through the DJ-1/MEKK1/JNK pathway
Click to check >>Author：Song Liu, Jianmin Ren, Shiyi Liu, Xiaoyan Zhao, Huiru Liu, Tingting Zhou, Xueying Wang, Haoyue Liu, Lei Tang, Heping Chen
IF：5.1950
Publish_to：EUROPEAN JOURNAL OF PHARMACOLOGY
PMID：37149277
Resveratrol exerts a protective effect in chronic unpredictable mild stress-induced depressive-like behavior: involvement of the AKT/GSK3β signaling pathway in hippocampus
Click to check >>Author：Shen J; Qu C; Xu L; Sun H; Zhang J
IF：4.4150
Publish_to：Psychopharmacology (Berl)
PMID：30374891
Discovery of the active compounds of Smilacis Glabrae Rhizoma by utilizing the relationship between the individual differences in blood drug concentration and the pharmacological effect in rats
Click to check >>Author：Gegentana;XuF;LiFC;ZhangYF;ShenSJ;YangP;YangXX;Sha
IF：4.2750
Publish_to：J Ethnopharmacol
PMID：32325179
Ultrasonic synthesis of nano-PrO1.8 as nanozyme for colorimetric determination of trans-resveratrol
Click to check >>Author：Wang L. Liu Y. Lu C. Yang Z. Liu Y. Wang Y. Rao H.
IF：4.1300
Publish_to：Sci Rep
PMID：32157164
Resveratrol inhibits LPS-induced apoptosis in bovine mammary epithelial cells: the role of PGC1α-SIRT3 axis
Click to check >>Author：Ouyang Lu, Tang Huilun, Liu Zilin, Tian Yuan, Gao Xin, Peng Tao, Wang Zuo, Lan Xinyi, Shen Weijun, Xiao Dingfu, Wan Fachun, Liu Lei
IF：2.7230
Publish_to：IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL
PMID：37173557
Resveratrol Treatment Is Associated with Lipid Regulation and Inhibition of Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) in Rabbits Fed a High-Fat Diet
Click to check >>Author：Xu L. Wang R. Liu H. Wang J. Mang J. Xu Z
IF：2.4000
Publish_to：Evid Based Complement Alternat Med
PMID：32595754
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