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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Endocrinology & Hormones > TamoxifenCAS：10540-29-1
Molecular Formula：C26H29NO
Molecular Weight：371.51
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 10540-29-1 |
| Name | Tamoxifen |
| Molecular Formula | C26H29NO |
| Molecular Weight | 371.51 |
| Solubility | Soluble in DMSO ≥25mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 234-118-0 |
| MDL | MFCD00010454 |
| SMILES | CC/C(C1=CC=CC=C1)=C(C2=CC=C(OCCN(C)C)C=C2)\C3=CC=CC=C3 |
| InChIKey | NKANXQFJJICGDU-QPLCGJKRSA-N |
| InChI | InChI=1S/C26H29NO/c1-4-25(21-11-7-5-8-12-21)26(22-13-9-6-10-14-22)23-15-17-24(18-16-23)28-20-19-27(2)3/h5-18H,4,19-20H2,1-3H3/b26-25- |
| PubChem CID | 2733526 |
| Target Point | Estrogen Receptor/ERR; HSP; Autophagy; Apoptosis |
| Passage | Endocrinology & Hormones;Cell Cycle;Metabolic Enzyme&Protease;Autophagy;Apoptosis |
| Background | It is a selective estrogen receptor modulator. It is also a potent Hsp90 activator that enhances the activity of the Hsp90 chaperone ATPase. Can activate autophagy and induce apoptosis. |
| Biological Activity | Tamoxifen是一种选择性雌激素受体调节剂 (SERM)，可阻断乳腺细胞中的雌激素作用，并可激活其他细胞，如骨骼，肝脏和子宫细胞中的雌激素活性。[1-4] |
| Data Literature Source | [1]. Osborne CK. Tamoxifen in the treatment of breast cancer. N Engl J Med. 1998 Nov 26;339(22):1609-18. [2]. Hawariah A，et al. In vitro response of human breast cancer cell lines to the growth-inhibitory effects of styrylpyrone derivative (SPD) and assessment of its antiestrogenicity. Anticancer Res. 1998 Nov-Dec;18(6A):4383-6. [3]. Jia Y，et al. Cardiomyocyte-Specific Ablation of Med1 Subunit of the Mediator Complex Causes Lethal DilatedCardiomyopathy in Mice. PLoS One. 2016 Aug 22;11(8):e0160755. [4]. Wang Y，et al. Evaluation of the safety and tolerability of tamoxifen for ischemia-incited renal injury in mice. Am J Transl Res. 2018 Jul 15;10(7):2184-2194. eCollection 2018. |
| Unit | Bottle |
| Specification | 10mg 10mM*1mL in DMSO 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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