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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Metabolic Enzyme & Protease > TheophyllineCAS：58-55-9
Molecular Formula：C7H8N4O2
Molecular Weight：180.16
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 58-55-9 |
| Name | Theophylline |
| Molecular Formula | C7H8N4O2 |
| Molecular Weight | 180.16 |
| Solubility | Soluble in Water ≥5mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 200-385-7 |
| MDL | MFCD00079619 |
| SMILES | O=C(N1C)N(C)C2=C(N=CN2)C1=O |
| InChIKey | ZFXYFBGIUFBOJW-UHFFFAOYSA-N |
| InChI | InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9) |
| PubChem CID | 2153 |
| Target Point | PDE;Adenosine Receptor;HDAC |
| Passage | Metabolic Enzyme&Protease;GPCR & G Protein;DNA Damage/DNA Repair;Epigenetics;NF-κB |
| Background | Theophylline is a non-selective phosphodiesterase (PDE) inhibitor, adenosine receptor blocker, and histone deacetylase (HDAC) activator. |
| Biological Activity | Theophylline (1，3-Dimethylxanthine) is a potent phosphodiesterase (PDE) inhibitor， adenosine receptor antagonist， and histone deacetylase (HDAC) activator. Theophylline (1，3-Dimethylxanthine) inhibits PDE3 activity to relax airway smooth muscle. Theophylline (1，3-Dimethylxanthine) has anti-inflammatory activity by increase IL-10 and inhibit NF-κB into the nucleus. Theophylline (1，3-Dimethylxanthine) induces apoptosis. Theophylline (1，3-Dimethylxanthine) can be used for asthma and chronic obstructive pulmonary disease (COPD) research[1-5]. |
| Data Literature Source | [1]. Rabe KF，et，al. Theophylline and selective PDE inhibitors as bronchodilators and smooth muscle relaxants. Eur Respir J. 1995 Apr;8(4):637-42. [2]. Németh ZH，et，al. Amrinone and theophylline differentially regulate cytokine and nitric oxide production in endotoxemic mice. Shock. 1997 May;7(5):371-5. [3]. Ichiyama T，et，al. Theophylline inhibits NF-kappa B activation and I kappa B alpha degradation in human pulmonary epithelial cells. Naunyn Schmiedebergs Arch Pharmacol. 2001 Dec;364(6):558-61. [4]. Ito K，et，al，Adcock IM，Barnes PJ. A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression. Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8921-6. [5]. Barnes PJ. Theophylline. Am J Respir Crit Care Med. 2013 Oct 15;188(8):901-6. |
| Unit | Bottle |
| Specification | 10mg 10mM*1mL in DMSO 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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