{{cart_num}}
My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > DNA Damage & DNA Repai > Valproic acid Sodium SaltCAS：1069-66-5
Molecular Formula：C8H15NaO2
Molecular Weight：166.19
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：GC≥97%
Appearance：White to off-white Solid
Qty：
Size：
| CAS | 1069-66-5 |
| Name | Valproic acid Sodium Salt |
| Molecular Formula | C8H15NaO2 |
| Molecular Weight | 166.19 |
| Solubility | Soluble in Water ≥50mg/mL;Soluble in DMSO ≥4mg/mL |
| Purity | GC≥97% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 213-961-8 |
| MDL | MFCD00078604 |
| SMILES | [O-]C(C(CCC)CCC)=O.[Na+] |
| InChIKey | AEQFSUDEHCCHBT-UHFFFAOYSA-M |
| InChI | InChI=1S/C8H16O2.Na/c1-3-5-7(6-4-2)8(9)10;/h7H,3-6H2,1-2H3,(H,9,10);/q;+1/p-1 |
| PubChem CID | 16760703 |
| Target Point | HDAC |
| Passage | DNA Damage/DNA Repair;Epigenetics |
| Background | It is an HDAC inhibitor that inhibits the activity of HDAC1 and induces the degradation of HDAC2. It can be used for research in epilepsy, bipolar disorder and migraine. |
| Biological Activity | Valproic acid sodium salt是一种用于治疗癫痫，双相情感障碍和偏头痛的抗惊厥化合物。 Valproic acid抑制组蛋白脱乙酰基酶1 (HDAC1) 的 IC50 为 0.4 mM。Valproic acid抑制VEGF，VEGFR2和bFGF的mRNA和蛋白质表达。Valproic acid抑制HDAC1的蛋白表达，增加组蛋白H3乙酰化，并增强高乙酰化组蛋白H3在VEGF启动子上的积累。[1-5] |
| Data Literature Source | [1]. Han BR，et al. Valproic acid inhibits the growth of HeLa cervical cancer cells via caspase-dependent apoptosis. Oncol Rep. 2013 Dec;30(6):2999-3005. [2]. Zhang ZH，et al. Valproic acid inhibits tumor angiogenesis in mice transplanted with Kasumi 1 leukemia cells. Mol Med Rep. 2013 Nov 28. [3]. Cohen OS，et al. Acute prenatal exposure to a moderate dose of valproic acid increases social behavior and alters gene expression in rats. Int J Dev Neurosci. 2013 Dec;31(8):740-50. [4]. Avery LB，et al. Valproic Acid Is a Novel Activator of AMP-Activated Protein Kinase and Decreases Liver Mass，Hepatic Fat Accumulation，and Serum Glucose in Obese Mice. Mol Pharmacol. 2014 Jan;85(1):1-10. [5]. Valproic acid，et al. Histone deacetylase is a direct target of valproic acid，a potent anticonvulsant，mood stabilizer，and teratogen. J Biol Chem. 2001 Sep 28;276(39):36734-41. |
| Unit | Bottle |
| Specification | 10mM*1mL in Water 50mg 10mM*1mL in DMSO 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Sorry, there is no more information.
Sorry, there is no more information.
Sorry, there is no more information.
Manual Download
