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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Membrane Transporter & Ion Channel > Verapamil HydrochlorideCAS：152-11-4
Molecular Formula：C27H38N2O4·HCl
Molecular Weight：491.07
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 152-11-4 |
| Name | Verapamil Hydrochloride |
| Molecular Formula | C27H38N2O4·HCl |
| Molecular Weight | 491.07 |
| Solubility | Soluble in DMSO ≥50mg/mL;Soluble in Ethanol ≥20mg/mL(Need ultrasonic) |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 205-800-5 |
| MDL | MFCD00069355 |
| SMILES | [H]Cl.COC1=CC=C(C(C#N)(C(C)C)CCCN(CCC2=CC=C(OC)C(OC)=C2)C)C=C1OC |
| InChIKey | DOQPXTMNIUCOSY-UHFFFAOYSA-N |
| InChI | InChI=1S/C27H38N2O4.ClH/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6;/h9-12,17-18,20H,8,13-16H2,1-7H3;1H |
| PubChem CID | 62969 |
| Target Point | Calcium Channel;P-glycoprotein |
| Passage | Membrane Transporter&Ion Channel;Neuronal Signaling |
| Background | Verapamil Hydrochloride is considered as a calcium antagonist. |
| Biological Activity | Verapamil hydrochloride 是钙离子通道 (calcium channel) 拮抗剂。[1-3] |
| Data Literature Source | [1]. Meister S，et al. Calcium channel blocker Verapamil enhances endoplasmic reticulum stress and cell death induced by proteasome inhibition in myeloma cells. Neoplasia. 2010 Jul;12(7):550-61. [2]. Yanjiao X，et al. Evaluation of the inhibitory effects of antihypertensive drugs on human carboxylesterase in vitro. Drug Metab Pharmacokinet. 2013;28(6):468-74. [3]. Zhou P，et al. Anti-arrhythmic effect of Verapamil is accompanied by preservation of cx43 protein in rat heart. PLoS One. 2013 Aug 12;8(8):e71567. |
| Unit | Bottle |
| Specification | 10mg 10mM*1mL in DMSO 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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