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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cytoskeleton > Vinblastine SulfateCAS：143-67-9
Molecular Formula：C46H58N4O9·H2SO4
Molecular Weight：909.05
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 143-67-9 |
| Name | Vinblastine Sulfate |
| Molecular Formula | C46H58N4O9·H2SO4 |
| Molecular Weight | 909.05 |
| Solubility | Soluble in Water/DMSO ≥10mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 205-606-0 |
| MDL | MFCD00082457 |
| SMILES | [H][C@@]12C[C@@](C3=C(OC)C=C(N([C@]4([H])[C@@]56[C@]7([H])[C@](C=CCN7CC6)(CC)[C@@H](OC(C)=O)[C@@]4(C(OC)=O)O)C)C5=C3)(C(OC)=O)C(NC8=C9C=CC=C8)=C9CC[N@](C2)C[C@](O)(CC)C1.OS(=O)(O)=O |
| InChIKey | KDQAABAKXDWYSZ-JKDPCDLQSA-N |
| InChI | InChI=1S/C46H58N4O9.H2O4S/c1-8-42(54)23-28-24-45(40(52)57-6,36-30(15-19-49(25-28)26-42)29-13-10-11-14-33(29)47-36)32-21-31-34(22-35(32)56-5)48(4)38-44(31)17-20-50-18-12-16-43(9-2,37(44)50)39(59-27(3)51)46(38,55)41(53)58-7;1-5(2,3)4/h10-14,16,21-22,28,37-39,47,54-55H,8-9,15,17-20,23-26H2,1-7H3;(H2,1,2,3,4)/t28-,37+,38-,39-,42+,43-,44-,45+,46+;/m1./s1 |
| PubChem CID | 241902 |
| Target Point | Microtubule/Tubulin;nAChR |
| Passage | Cytoskeleton;Neuronal Signaling;Membrane Transporter&Ion Channel |
| Background | Vinblastine inhibits the formation of microtubules. |
| Biological Activity | Vinblastine sulfate是一种针对各种癌症类型的有细胞毒性的生物碱。 长春花碱可抑制微管的形成，抑制nAChR的IC50值为8.9 μM。[1-4] |
| Data Literature Source | [1]. McKay DB，et al. Nicotinic and nonnicotinic receptor-mediated actions of vinblastine. Proc Soc Exp Biol Med. 1993 Jul; 203 (3) :372-6. [2]. Pandya P，et al. Molecular recognition pattern of cytotoxic alkaloid vinblastine with multiple targets. J Mol Graph Model. 2014 Nov; 54:1-9. [3]. Calvi o E，et al. JNK and NFκB dependence of apoptosis induced by vinblastine in human acute promyelocytic leukaemia cells. Cell Biochem Funct. 2015 Jun; 33 (4) :211-9. [4]. Selimovic D，et al. Vinblastine-induced apoptosis of melanoma cells is mediated by Ras homologous A protein (Rho A) via mitochondrial and non-mitochondrial-dependent mechanisms. Apoptosis. 2013 Aug; 18 (8) :980-97. [5]. Bánóczi Z，et al. Synthesis and in vitro antitumor effect of vinblastine derivative-oligoarginine conjugates. Bioconjug Chem. 2010 Nov 17; 21 (11) :1948-55. |
| Unit | Bottle |
| Specification | 10mg 10mM*1mL in Water 10mM*1mL in DMSO 20mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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