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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > WogoninCAS：632-85-9
Molecular Formula：C16H12O5
Molecular Weight：284.26
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 632-85-9 |
| Name | Wogonin |
| Molecular Formula | C16H12O5 |
| Molecular Weight | 284.26 |
| Solubility | Soluble in DMSO ≥5mg/mL |
| Purity | HPLC≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 1592732-453-0 |
| MDL | MFCD00017736 |
| SMILES | O=C1C=C(C2=CC=CC=C2)OC3=C(OC)C(O)=CC(O)=C13 |
| InChIKey | XLTFNNCXVBYBSX-UHFFFAOYSA-N |
| InChI | InChI=1S/C16H12O5/c1-20-15-12(19)7-10(17)14-11(18)8-13(21-16(14)15)9-5-3-2-4-6-9/h2-8,17,19H,1H3 |
| PubChem CID | 5281703 |
| Target Point | CDK |
| Passage | Cell Cycle |
| Background | Wogonin is a flavonoid that inhibits the activity of CDK8 and Wnt signaling pathways. |
| Biological Activity | Wogonin 是一种天然黄酮类物质，能够抑制 CDK8 and Wnt 的活性，具有抗炎、抗肿瘤等功效。[1-3] |
| Data Literature Source | [1]. He L，et al. Wogonin induced G1 cell cycle arrest by regulating Wnt/β-catenin signaling pathway and inactivating CDK8 in human colorectal cancer carcinoma cells. Toxicology. 2013 Oct 4;312:36-47. [2]. Yang L，et al. Wogonin induces G1 phase arrest through inhibiting Cdk4 and cyclin D1 concomitant with an elevation in p21Cip1 in human cervical carcinoma HeLa cells. Biochem Cell Biol. 2009 Dec;87(6):933-42. [3]. Li HD，et al. Wogonin attenuates inflammation by activating PPAR-γ in alcoholic liver disease. Int Immunopharmacol. 2017 Sep;50:95-106. |
| Unit | Bottle |
| Specification | 10mg 10mM*1mL in DMSO 20mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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